Intro Flashcards
Which COX converts free arachidonic acid to prostaglandin G2?
Dioxygenased
Which COX converts prostaglandin G2 to prostaglandin H2?
Peroxidased COX
What does aspirin decrease production of in platelets?
TxA2
What is vitamin K a cofactor for?
II, X, VII, IX
Why does uric acid cause bladder stones in a Dalmatian?
Lack liver transpoter
Which pseudogene is unexpressed in cats?
Tas1R2
What does B2 adrenoceptor have phosphorylation sites for?
PKA and BARK
What inhibits the ca2+ release cycle?
Lithium
What can activate K+ inward rectifiers?
Ca2+. GPCR, ATP
What are the AChR agonist and antagonist in smooth muscle?
Muscarine and atropine
What are the AChR agonist and antagonist in skeletal muscle?
Nicotine and d-tubocurarine
Does k+1 or
k-1
What is P2X a receptor for?
ATP
Structure of PKA?
A heterotetramer
What anchors PKA and cAMP?
AKAP
Where does DAG remain?
Membrane
Where are IP3 receptors?
The ER
What are RRSS in the B2 adrenoceptor?
Potential sites for phosphorylation by PKA
What is v-erbB?
Constitutively active EGF receptor
What is c-erbB
Overexpressed in squamous cell carcinoma
What is v-sis?
PDGF chain in simian sarcoma virus
Which curve does heterologous desensitization follow?
Response
Which desensitization happens at a lower concentration?
Heterologous
Where is lidocaine most effective?
Ischaemic tissues
What does quinidine act on?
Supraventricular tachycardia
What does batrachoctoxin do?
Causes channel to activate at higher potentials
Where do DHPs bind?
Smooth muscle/vascular
