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MODA > Intro > Flashcards

Intro Flashcards

1
Q

Which COX converts free arachidonic acid to prostaglandin G2?

A

Dioxygenased

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2
Q

Which COX converts prostaglandin G2 to prostaglandin H2?

A

Peroxidased COX

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3
Q

What does aspirin decrease production of in platelets?

A

TxA2

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4
Q

What is vitamin K a cofactor for?

A

II, X, VII, IX

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5
Q

Why does uric acid cause bladder stones in a Dalmatian?

A

Lack liver transpoter

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6
Q

Which pseudogene is unexpressed in cats?

A

Tas1R2

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7
Q

What does B2 adrenoceptor have phosphorylation sites for?

A

PKA and BARK

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8
Q

What inhibits the ca2+ release cycle?

A

Lithium

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9
Q

What can activate K+ inward rectifiers?

A

Ca2+. GPCR, ATP

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10
Q

What are the AChR agonist and antagonist in smooth muscle?

A

Muscarine and atropine

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11
Q

What are the AChR agonist and antagonist in skeletal muscle?

A

Nicotine and d-tubocurarine

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12
Q

Does k+1 or

A

k-1

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13
Q

What is P2X a receptor for?

A

ATP

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14
Q

Structure of PKA?

A

A heterotetramer

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15
Q

What anchors PKA and cAMP?

A

AKAP

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16
Q

Where does DAG remain?

A

Membrane

17
Q

Where are IP3 receptors?

A

The ER

18
Q

What are RRSS in the B2 adrenoceptor?

A

Potential sites for phosphorylation by PKA

19
Q

What is v-erbB?

A

Constitutively active EGF receptor

20
Q

What is c-erbB

A

Overexpressed in squamous cell carcinoma

21
Q

What is v-sis?

A

PDGF chain in simian sarcoma virus

22
Q

Which curve does heterologous desensitization follow?

A

Response

23
Q

Which desensitization happens at a lower concentration?

A

Heterologous

24
Q

Where is lidocaine most effective?

A

Ischaemic tissues

25
Q

What does quinidine act on?

A

Supraventricular tachycardia

26
Q

What does batrachoctoxin do?

A

Causes channel to activate at higher potentials

27
Q

Where do DHPs bind?

A

Smooth muscle/vascular

MODA (10 decks)

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