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MODA > Anthelmintics > Flashcards

Anthelmintics Flashcards

1
Q

Which are the inhibitory ligand gates channels?

A

GABA-R, Glu-R and SLO-1

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2
Q

What does Glu-R let in?

A

Chloride

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3
Q

What is the latrophilin receptor permeable to?

A

Ca2+

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4
Q

What is sweet itch?

A

Type I hypersensitivity to midge saliva

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5
Q

Where does demodex live?

A

Hair follice

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6
Q

Where is an acaricide active against?

A

Ticks and mites

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7
Q

What is an insecticide active against?

A

Insects

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8
Q

How to contact poisons pass through ectoskeleton?

A

Between chitin plates

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9
Q

Where are inhibitory glutamate Cl- channels found?

A

Pharynx and egg laying muscles

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10
Q

What do cysteine proteases do?

A

Break down collagen by hydrolysing peptide bond and reducing egg production

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11
Q

How many helminth AChE gene are there?

A

3

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12
Q

What does SLO-1 activation presynaptically cause?

A

Hyperpolarisation so no transmission

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13
Q

What does SLO-1 activation post-synaptically do?

A

Hyperpolarisation

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14
Q

What are the two types of inhibitory hyperpolarising K+ channels?

A

One Ca2+ activated and one like the SLO channel

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15
Q

What does the LLR do?

A

Hyperpolarises post-synaptic membrane

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16
Q

What is a nematode?

A

Round worm

17
Q

What is a trematode?

A

FLuke

18
Q

What is a cestode?

A

Tape worm

19
Q

What are the three types of AChE in a helminth?

A

1,2,3

20
Q

How does glutamate cause its inhibitory effect?

A

Acts on LLR GPCR, activates PLC, makes DAG/IP3, activates UNCI3 and synaptobrevin, causes neurotransmitter release which hyperpolarises post synaptic membrane

21
Q

How do pyrethroids work?

A

Excitotoxin - delay opening and closing of Na+ channel

22
Q

Which pyrethroids degreade in sunlight?

A

Type I

23
Q

What must pyrethroids be synergised with?

A

BPO

24
Q

What does piperonl butoxide do?

A

Type I pyrexin potentiator

25
Q

What does formamidines do?

A

Octopamine (inhibitory) receptor inhibitor

26
Q

What is the octopamine receptor like?

A

DOpamine

27
Q

What do phenylpyrazoles do?

A

Inhibit GABA

28
Q

What do nitroguanidines do?

A

nAChR blocker

29
Q

What do metaflumizone, indoxacarb, pyriproxifen do?

A

Nerve Na+ channel blocker

MODA (10 decks)

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