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MODA > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

What does transglycosylase do?

A

Crosslinks glycan strands and extends chains

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2
Q

What does transpeptidase do?

A

Crosslinks peptide strands

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3
Q

What does bactoprenol do?

A

Forms phosphate bridge with the cell wall precursor so it can be transported to teh outer membrane

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4
Q

What kind of hydrolases are transpeptidases?

A

Serine hydrolases

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5
Q

Which are the aminoglycosides?

A

Streptomycin and gentamycin

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6
Q

Which is the macrolide?

A

Erythromycin

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7
Q

Which are 30S subunit?

A

Tetracycline and streptomycin

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8
Q

Which are 50S subunit?

A

Chloramphenicol and erythromycin

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9
Q

Which bacteria are aminoglycosides inhibited in?

A

Gram -ves

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10
Q

What is chloramphenicol used to treat?

A

Typhus and bacterial meningitis from H influenzae or N meningitidis

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11
Q

What does fusidic acid used for?

A

Skin and eye infections by gram +ves

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12
Q

Which infections are fluoroquinolones used against?

A

UTIs, osteomyelitis, pneumonia, gastroenteritis, anthrax and pseudomonas

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13
Q

What is rifampin used to treat?

A

TB

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14
Q

What is co-trimoxazole used to treat?

A

Pneumocystis

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15
Q

What is polymixin used to treat?

A

Resistant pseudomonas

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16
Q

What is amphotericin B active against?

A

Cryptococcus, aspergillus, candida

17
Q

What is melarsen used to treat?

A

Trypanosoma

18
Q

What is suramin used to treat?

A

Trypanosoma

19
Q

What does sodium stibogluconate treat?

A

Leishmaniasis

20
Q

What is fansidar used against?

A

Plasmodium

21
Q

What is IFN-alpha-2a used to treat?

A

HBV and AIDS Kaposi sarcomas

22
Q

What is IFN-alpha-2b used to treat?

A

HCV

23
Q

Which receptors do IFNs act on?

A

Ganglioside

24
Q

Which active site do A C and D have?

A

Serine

25
Q

What do B lactamases do?

A

Use zinc to activate a water molecule and add it to the ring

26
Q

What are vancomycin resistant bacteria called?

A

VanA and VanB

27
Q

Which enzymes do vancomycin resistant bacteria have?

A

VanH, VanA and VanX

28
Q

Which proteins do vancomycin resistant bacteria have?

A

VanS and VanR

29
Q

Which bacteria has lots of efflux transporters?

A

Pseudomonas

30
Q

Which regulon controls MDR in E coli?

A

MAR

31
Q

What makes up HAART?

A

Protease inhibitor + reverse transcriptase inhibitor

32
Q

What shows the points where drug efficacies overlap?

A

Isobologram

33
Q

What is dose proportional to with new anticancer agents?

A

Body surface area

34
Q

What is a phase II trial?

A

Anti-tumour efficacy

35
Q

What is a phase III trial?

A

Comparison with best available therapy

MODA (10 decks)

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