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Virology > Intro > Flashcards

Intro Flashcards

1
Q

Viruses genome type (general)

A

Either DNA or RNA (Not Both)

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2
Q

Virus organelles

A

None

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3
Q

Do viruses contain Muramic acid?

A

No

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4
Q

Do viruses have ribosomes?

A

No, mostly.Areanavuris packages ribosomes “accidentally”

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5
Q

Classical virus classification scheme based on what 4 properties?

A
  1. Genome type (size, strandedness, shape, +/-, segment)2. Symmetry3. Lipid membrane4. Virion/Capsid size
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6
Q

ICTV classification emphasizes what?

A

The viral genomeAlso based on viral structure (symmetry, icosahedral, helical, enveloped vs non-enveloped)

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7
Q

Baltimore classification

A

clusters into family based on the TYPE of genome*complement to ICTV

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8
Q

Baltimore DNA viruses

A

Groups 1 + 21. +/- dsDNA2. + ssDNA

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9
Q

Baltimore RNA viruses

A

Groups 3,4,53. +/- dsRNA4. + ssRNA5. - ssRNA

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10
Q

Which type of RNA virus is complimentary to RNA

A

-ssRNAIt has to create (+) strand to generate mRNA for protein synthesis

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11
Q

Copying of which strand of dsRNA will generate mRNA?

A

Negative (-) strand

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12
Q

Baltimore retroviruses

A

Groups 6 + 76. +ssRNA7. +/-dsDNA

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13
Q

RNA viruses typically have a _____ genome

A

Smallerdue to higher error rate

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14
Q

dsRNA viruses – two properties

A

One pieceSegmented

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15
Q

DNA viruses single or double stranded?

A

Both!

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16
Q

Virus genomes are ____ (referring to # of copies). Which virus is the exception?

A

HaploidRetroviruses (have two copies)

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17
Q

Capsid definition

A

Protein (VIRAL) shell surrounding the nucleic acid

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18
Q

Nucleocapsid made of…

A

Capsid + Nucleic Acid

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19
Q

Helical virus capsid is ______ and made of _________?

A

cylindrical made of capsomere surrounding the RNA

20
Q

Polyhedral virus capsid components

A

Capsomere and spikes

21
Q

Capsid made of ____ proteins

A

Viral

22
Q

Capsid is more or less stable than envelope?

A

More!

23
Q

Capsid is stable to what things?

A
  1. Temp2. pH3. Proteases4. Detergents5. Drying
24
Q

Viral envelope composed of

A

Lipid, protein, glycoproteinMembrane from host, proteins from virus

25
Q

All ____ have an envelope

A

Negative strand RNA viruses

26
Q

Glycoproteins in envelope are for…

A

Viral attachment

27
Q

Capsid viruses released by…

A

cell lysis

28
Q

Enveloped viruses are released by…

A

either BUDDING or LYSIS

29
Q

Which type of virus (capsid/enveloped) elicits hypersensitivity and inflammation?

A

EnvelopedThis causes immunopathogenesis

30
Q

Naked capsid virus components

A

Nucleic AcidStructural ProteinEnzymes/NA-binding proteins =Nucleocapsid

31
Q

Components of Enveloped virus

A

-Nucleocapsid (NA+Structural/Enzyme Proteins)-Glycoproteins -Membrane

32
Q

DNA virus categories

A

-DS-SS Non enveloped-Complex Enveloped

33
Q

Enveloped dsDNA Viruses

A

HerpesHepaDNA

34
Q

Non-Enveloped dsDNA Viruses either…

A

Circular or Linear

35
Q

Circular Non-Enveloped dsDNA

A

PapillomaPolyoma(formerly grouped together as PAPOVAviridae)

36
Q

Linear Non-Enveloped dsDNA

A

Adeno

37
Q

All DNA viruses are _______ except for _______

A

IcosahedralPoxviruses

38
Q

RNA Virus categories

A

ss+ss-ds

39
Q

RNA virus subcategories

A

**draw the chart**

40
Q

Major viral replication steps (5)

A
  1. Recognition / attachment2. Penetration / uncoating3. Synthesis of NA and protein -early mRNA synth –Replication —Late mRNA synthesis —-Posttranslational Mod4. Assebly5. Budding (or Lysis)
41
Q

Growth curve for virus from lysis is…

A

one step

42
Q

Steps for one step growth curve

A

Adsorption/EntryUncoating and Replication (ECLIPSE)MaturationViral Release

43
Q

During Eclipse period, what happens?

A

infectivity dissappears

44
Q

What happens during latent period?

A

replication of NA and Protein

45
Q

Attachment requires what process?

A

Recognition of receptor on host cell (for entry)

46
Q

Non-Enveloped viruses penetrate by what methods?

A

Endocytosis (RME)Viropexis (direct)

47
Q

Enveloped viruses penetrate by what methods?

A

Fusion (pH dependent)At Low pH – Fusion occurs in ENDOSOMENormal pH – Membrane fusion occurs at surface

Virology (15 decks)

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