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Virology > Arbo 3 > Flashcards

Arbo 3 Flashcards

1
Q

Reoviridae genus

A

Coltivirus: Colorado Tick Fever Virus

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2
Q

Coltivirus structure

A
  • 12 Double stranded RNA segments
  • NON enevloped
  • icosahedral
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3
Q

Coltivirus replication cycle (5 steps)

A
  1. endocytosed, enters lysosome
  2. core particle primary transcript
  3. Translated into +/- strands in cytoplasm
  4. replicase creates + strand from the - one
  5. capsid assembly and release
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4
Q

Colorado tick fever is a ____, _____ illness

A

nonspecific, febrile

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5
Q

Coltivirus clinical findings (4)

A
  1. Tick bite
  2. Saddleback Fever
  3. Flu-like symptoms
  4. Transient Rash

(Complication of Encephalitis or pericarditis)

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6
Q

Coltivirus infects _______ cells.

What effect does this have?

A

Bone Marrow cells

this halts development of blood cell types (PMN, eos, baso’s)

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7
Q

When do Coltivirus symptoms occur

A

4-5 days after tick bite

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8
Q

Significance of the first two weeks of Coltivirus infection

A

free virus can be found in the blood

after which it circulates within erythroblasts

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9
Q

When does Coltivirus antibody appear?

A

two weeks after symptom onset

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10
Q

Coltivirus lifespan in blood

A

can be isolated for 6 weeks

BUT can live in RBC for life of the cell

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11
Q

Coltivirus resevoir and transmitter

A

Squirrel/rodent resevoir

Wood Tick is transmitter

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12
Q

What tick spreads Coltivirus?

A

Rocky Mountain wood tick

(Dermacentor andersoni)

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13
Q

90% of Coltivirus cases happen during…

A

april-july

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14
Q

Coltivirus control

A

stay away from ticks

check yo pets

get out of your skin if embedded

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15
Q

Filoviridae diseases

A

Ebola

Marburg

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16
Q

Characteristics that filoviridae share

A

Genome structure

Zoonotic

Damage the microvasculature = hemorrhage

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17
Q

Filovirus organism structure

A

ss (-) RNA

Encodes 7 proteins

Enveloped filaments

Helical

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18
Q

Filovirus nucleocapsid enclosed in an envelope that contains…

A

one glycoprotein

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19
Q

Filovirus replicates in the

A

cytoplasm

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20
Q

Filovirus (ebola) causes ______ infection

A

hemorrhagic

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21
Q

Ebola rash appearance and time

A

macropapular, appears at 5 days

22
Q

Signs of recovery occur at day ____ and are concurrent with…

A

Day 7

With antibody response

23
Q

Ebola transmission and reservoir

A

Unknown

possibly bats

24
Q

Major characteristic of Ebola (filo) infection is…

A

destruction of the immune system

especially the breakdown of endothelial cells

25
Q

Ebola cell damage due to ____

A

Cytokine release from Monocytes

26
Q

Ebola cytokine dysregulation promotes ______ and ______

A

hemorrhage + vasomotor collapse

27
Q

Ebola vector

A

Not identified

28
Q

Rotavirus serogroups

A

A-E

29
Q

Rotavirus genome and structure

A

nonenveloped

dsRNA

3 capsid layers + inner core

(Outer capsid VP4)

30
Q

Rotavirus VP4 protein is located on _____ and functions to aid _______

A

Outer capsid

host attachment

31
Q

Is rotavirus segmented or not?

A

Yes

11 segments of dsRNA

32
Q

Rotavirus transcription and translation occur in _______

A

Inner core = transcription

Cytoplasm = translation

33
Q

What is different about the replication of Rotavirus?

A

replicates in progeny core

uses positive RNA template

34
Q

Rotavirus release from cell, two steps…

A

buds into ER

release by cell lysis

35
Q

Rhabdovirus genus

A

Lyssavirus

36
Q

Rhabdo shape and structure

A

bullet shaped helical, enveloped

ss (-) RNA

37
Q

Rhabdo: associated proteins

A

NPMGL

(nucleo, phospho, matrix, glyco, polymerase)

38
Q

Rhabdo replication

A
  1. Binds using G protein
  2. Pinocytosis into cytoplasm
  3. Endosome fusion and release RNP into cytoplasm
  4. L gene (pol-ase) makes 5 mRNAs + 1 full (+)RNA
  5. Translation of NPMGL (G = processed in ER and Golgi)
  6. +RNA serves as templates for full length (-) RNA
  7. Assemble NPL around RNP core, M forms capsule (matrix)
  8. Bud from PM and release
39
Q

Rhabdo periods (and # of days for each)

A

Incubation (20-90)

Prodromal (2-10)

Neurological (2-7)

40
Q

Rhabdo travels via..

A

retrograde axonal transport

41
Q

Rhabdo pathogenesis duration depends on…

A

size & site of exposure

human/animal immunity

42
Q

Rhabdo replicates in _____

A

muscle at the site of innoculation

43
Q

Rhabdo concentrates in ______

A

salivary glands

44
Q

common reservoirs for rhabdo

A

bats, foxes, raccoons, skunks

45
Q

Rhabdo Dx

A

Histopathology

(also electron micro,

direct elisa/immunochemistry)

46
Q

signs of rhabdo in histopathology are… (5)

A
  1. mononuclear infiltration
  2. perivascular cuffing (lymph/PMN)
  3. Lymphocytic foci
  4. Babes nodules
  5. NEGRI BODIES
47
Q

Rhabdo vaccine is unique in that it is adminitered

A

Post exposure

48
Q

Other measures taken after exposure to rhabdo (other than post exposure vax)

A

Clean site with soap and water

49
Q

Rhabdo vax administration schedule after exposure?

A

Days - 0, 3, 7, 14, 28

50
Q

Is there a pre exposure rhabdo vaccine?

A

Yes

3 doses

51
Q

What is the Wisconsin rabies treatment protocol?

A

Ketamine

Ribavirin

Amantadine

Virology (15 decks)

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