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Virology > Arbo 1 > Flashcards

Arbo 1 Flashcards

1
Q

Bunya Family includes what genuses

A

Bunyavirus

Hantavirus

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2
Q

Families of Arbovirus

A

Bunya

Flavi

Toga

Reo

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3
Q

Flavivirus serotypes

A

SLE

Dengue

Yellow Fever

JEE

West Nile

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4
Q

Hantavirus serotype

A

Sin Nombre

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5
Q

Bunyavirus serotypes

A

California + Lacrosse

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6
Q

Togaviridae genuses

A

Rubella

Alphavirus

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7
Q

Alphavirus serotypes

A

EEE, WEE, VEE

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8
Q

Reoviridae genus and Serotypes

A

Rotavirus

Coltivirus (Serotype = Colorado Tick Fever Virus)

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9
Q

Two types of transmission cycles

A

Man > Arthropod > Man

Animal > Arthropod > Man

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10
Q

Arbovirus that displays BOTH transmission cycle types

A

Yellow Fever

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11
Q

Arboviruses that have Animal-Arthropod-Man cycle:

A

Japanese Encephalitis

WEE, EEE

_Jungle _Yellow fever

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12
Q

Arboviruses that show Man-Arthropod-Man cycle

A

Dengue

Urban Yellow Fever

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13
Q

Most arboviruses have what host

A

mosquito

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14
Q

Which Arboviruses have tick host

A

Colorado Tick Fever

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15
Q

Other animal reservoirs

A

Birds (JE, SLE, EEE, WEE)

Pigs (JE)

Monkeys (YF)

Rodents (VEE, Hantavirus)

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16
Q

___ and ___ cause hemorrhagic fever

A

yellow fever, dengue

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17
Q

Dx for arboviruses

A

Serology (USUALLY)

Culture

Direct detection tests

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18
Q

Bunyavirus human disease:

A

LaCrosse Encephalitis

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19
Q

Bunyavirus genus that we’re concerned with

A

California Group (causes LaCrosse)

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20
Q

Bunyavirus structure

A

Enveloped Segmented (-)RNA

Helical capsid

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21
Q

Bunyavirus segments

A

L, M, S

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22
Q

Bunyavirus carries ____

A

Transcriptase

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23
Q

Most common cause of pediatric arboviral encephalitis

A

Bunyavirus

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24
Q

Arbovirus infects ______ system

A

Reticuloendothelial

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25
Q

_______ can block secondary viremia in arboviruses

A

Antibodies

26
Q

Highest incidence of LaCrosse virus is in…

A

the midwest

(Ohioooooo)

27
Q

Major reservoir of LaCrosse (Bunya)

A

Chipmunks + Squirrels

28
Q

LaCrosse Serology: When does antibody titer increase?

A

Between the acute and convalescent phases

29
Q

Lacrosse virus has not been….

A

isolated from CSF

30
Q

CSF characteristics for LaCrosse infection

A

Normal-ish ICP

Normal Glucose

Mildly high Protein

PMN Pleocytosis

31
Q

LaCrosse Encephalitis Brain biopsy can show…

A

Perivascular infiltration with Mononuclear Cells

32
Q

Bunyavirus Control and Treatment

A

No Treatment or vaccine

33
Q

Hantavirus: 2 clinical presentations-

A
  1. HPS = Hantavirus Pulmonary Syndrome (Sin Nombre)
  2. HFRS = Hemorrhagic Fever w Renal Syndrome*

*In Asia

34
Q

HPS (Sin Nombre) characterized by a ____ followed by acute respiratory failure

A

febrile prodrome

35
Q

HPS Symptom Stages

A

Early (flu like)

Late (Pulmonary)

36
Q

HFRS initial symptoms

A

Head/Body ache

FEVER

Nausea

Inflammation/ Redness of eyes

Rash

37
Q

HFRS Later Symptoms

A

Low BP

Shock

Vascular leakage

ARF

38
Q

Hantavirus primarily targets ______ cells after dissemination

A

Vascular Endothelial

esp. in heart, lung, lymph

39
Q

Hantavirus causes __________ because of increased capillary permeability

A

protein-rich edema

(and Interstitial Pneumonitis of edema fluid, mononuclear cells, and lymph/leukocytes)

40
Q

Hantavirus reservoir

A

Deer Mouse

41
Q

Humans get infected by Hantavirus by what 3 ways?

A

inhalation of rodent waste

rodent bite

contact with excretion of rodent

42
Q

Hantavirus Dx

A

Serology IgM and IgG

Immunochemistry

RT-PCR

43
Q

Hantavirus Tx

A

Supportive care (Fluid, BP, O2)

44
Q

Flaviviruses hosts

A

Broad range

45
Q

Flavivirus genome/structure

A

Positive ssRNA (resembles mRNA)

Icosahedral

Enveloped

46
Q

Flavivirus replicates in the ______, and is released by ______

A

cytoplasm, exocytosis

47
Q

Flavivirus two general types of diseases:

A
  1. Encephalitis (SLE, JE, West Nile)
  2. Hemorrhagic Fever (Dengue, Yellow Fever)
48
Q

SLE incubation period

A

4-21 Days

49
Q

SLE is a severe ____ disease that causes ________

A

neuroinvasive

encephalitis

50
Q

SLE (Flavi) virus is produced (in body) in the ______, and then causes _______

A

Produced in site of innoculation,

causes primary viremia

51
Q

SLE is cleared from system by ________

A

reticuloendothelial system

52
Q

Secondary viremia during SLE leads to ________

A

invasion of CNS

53
Q

After healing from SLE, __________ occurs

A

Spongiform changes

54
Q

SLE CSF examination shows

A

mononuclear pleocytosis

Elevated protein

Normal Glucose

55
Q

SLE lab Dx

A

Serum or CSF

to detect IgM and Antibodies

56
Q

Japenese Encephalitis (JE) Stages

A
  1. Early - Fever, diarrhea, rigor (and reduced consciousness)
  2. Later - Flaccid paralysis and Parkinsonian syndrome
57
Q

Pahtogenesis of JE (5 steps)

A
  1. Mosquito bites
  2. Multiplication in RE system
  3. Viremia
  4. Transport to Brain
  5. Proliferation and damage
58
Q

JE hosts/vectors

A

Animals can act as hosts/intermediates

Humans are DEAD-END hosts

59
Q

JE Treatment

A

None

60
Q

JE vaccine

Who is it recommended for?

A

Purified formalin-inactivated vaccine (3 doses)

NOT RECOMMENDED FOR TRAVELERS

Virology (15 decks)

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