Intracelular Accumulation Flashcards
With fatty droplets in the liver, what rate is inadequate
Rate of metabolism
With lysosomal storage dx, what causes accumulation
Defect in enzyme required for its metabolism
In neurodegenerative diseases, what causes accumulation
Product of mutated gene or misfolded proteins cannot be degraded
Example of abnormal exogenous cell accumulation
Carbon particles in alveolar macrophages
Steatosis occurs mainly in
The liver
Causes of steatosis
Alcohol abuse, diabetes, obesity
CCl4 and Protein malnutrition
Hypoxia
Starvation
Special stains used to identify fatty droplets microscopically
Sudan black
Oil Red-O
Cholesterol accumulation causes
Atherosclerosis in Blood vessels
Xanthomas in connective tissue and skin
Cholesterolosis in gall bladder
Niemann-Pick disease type C
In cholesterolosis, the surface appearance of the mucosa of the gall bladder resembles
Strawberry
In proteinuria, droplets in
Proximal renal tubules
Immunoglobulins may accumulate where, producing what
In plasma cells within the ER, producing inclusions called RUSSELL BODIES
In emphysema, what enzyme is deficient and why
Alpha 1 antitrypsin
The enzyme’s precursors are misfolded and have accumulated in the liver
Accumulation of cytoskeletal proteins
- Alcoholic liver disease- Keratin intermediate filaments in alcoholic hyaline
- Alzheimer’s disease - Neurofilaments in neurofibrillary tangles
Name an example of aggregation of abnormal proteins
Amyloidosis
In DM, normal glucose uptake by cells is impaired. This is seen in (histology)
Hepatocytes (stained by PAS/PASD)
