Cell death Flashcards
1
Q
Antiapoptotic proteins
A
BCL2, BCLXL, MCL1
2
Q
Anti-apoptotic proteins prevent
A
Leakage of Cytochrome C
3
Q
Pro-apoptotic proteins
A
BAX, BAK
4
Q
Cytochrome C activates
A
Caspases
5
Q
Regulation of anti and pro-apoptotic proteins
A
BH3-only proteins- BID, BAD, BIM, Puma
6
Q
Major mechanism for apoptosis in all mammalian cells
A
Mitochondrial/Intrinsic pathway
7
Q
The extrinsic pathway can be inhibited by a protein called
A
FLIP
8
Q
DNA damage caused the accumulation of ………. protein
A
p53
9
Q
Absence of p53 in what disease
A
Li Fraumeni Syndrome
