Intracellular Compartments and Protein Sorting Flashcards
Know the major intracellular components of an animal cell.
ok
Proteins that have crossed a membrane are no longer topologically inside the cell. They must recross the membrane to get back inside the cell.
ok
Vesicles move from compartment to compartment within a cell by __________ and __________.
budding off and membrane fusion
Many proteins have signal sequences at their _____ terminus that direct the proteins to cross the membrane. Fewer proteins have ________ signal sequences.
amino terminus; internal
The nucleus is surrounded by a ______________________ however nuclear ores allow molecules, including ________, to pass from the cytosol to the nucleus and ____.
double lipid membrane bilayer
proteins
back
larger proteins pass through nuclear pores by and ____ process
active
nuclear import receptors bind to nuclear transport signals found on some nuclear bound proteins and facilitate transport into the nucleus
ok
it generally requires _______ signals to transport proteins from the ___ into the _______.
multiple
cytosol
lumen of mitochondria
there are multiple protein _________ in the mitochondrial membrane. Each interacts with a specific __________.
translocators
set of proteins
transport of PRO into mitochondria requires _____
energy
PRO enter _________ using a mechanism similar to mitochondrial entry.
peroxisomes
PRO travel from ______ through the _______ to many sites.
ER
Golgi
A ______ _______ protein (SRP) bind to the signal sequence during _________ and directs the __________ _______ to the ER membrane.
signal recognition protein (SRP)
translation
nascent peptide
PRO meant for the mito are translated in the cyto and transported through the mito membrane, which requires _____
ATP
PRO headed through the ER are transported through the ER during translation (ribosomes on ER surface). This process requires ____
no additional energy
