Drug Resistance

Question 1

Drug metabolism can take place anywhere in the body (plasma, kidney, lung, gut wall) but __ is prime site.

Answer 1

liver

Question 2

What are the three potential outcomes of drug metabolism?

Answer 2

1. ) Increase in drug hydrophilicity and ability to be excreted (hepatic)
2. ) Metabolic products are less pharmacologically active than the substrate drug
3. ) Inactive prodrugs converted to their active forms (hepatic)

Question 3

There are 5 mechanisms of drug resistance:

Answer 3

1. ) decreased permeability
2. ) alteration of the drug’s target site
3. ) enzymatic inactivation of the drug
4. ) active transport of the drug outside of the cell
5. ) amplification of the gene coding for the target of the drug

Question 4

An _________ in DNA repair activity can _________ effective ness of drugs that target DNA.

Answer 4

increase

decrease

Question 5

multidrug resistant results from an _________ in the amt of __________ proteins that can pump many different drugs _____ of the cell.

Answer 5

increase
transporter
out