Intracellualr Accumulation And Celkular Aging Flashcards
Steosis is
Accumulation of fat inside cells
Special stains used to test for lipid ( fat)
Oil red o
And
Sudan IV
If the cells has lipid and Sudan IV is used
What color change shows a positive lipid present
Orange colour
Fatty liver is it reversible
Yes
Atherosclerosis is
Smooth muscle cells having a lipid vacuole filled with cholesterol
So atherosclerosis is accumution of cholesterol
Xanthoma is what
Cholesterol build up in connective tissue under the skin
Characteristic of tuton gigantic cells
Steosis usually occur in what organ
Liver. Majorly
Kidney tubule
Heart and skeletal muscle
In the kidney albumin filtered by glomerular filteration is reabsorbed by
Pinocytosis in the proximal tubule
Accumulation of immunoglobulin presents with what at rough endoplasmic reticulum
Eosinophilic Russell bodies
Russell bodies indicate
An accumulation of immunoglobulin
Mallory body is an indication of
Alcoholic liver disease
Sudan IV AND OIL red o are
Stains used to test for lipid
Sudan iv stains lipid what color
Orange
Stains used to test for glycogen are
Periodic acid schiff and best carmine
Period acid schiff is
A stain used to test for presence of glycogen
Best carmine is
A stain used to test for glycogen presence
Oil red o is
A stain used to test for lipid
What stain color indicates the presence of glycogen
Rose to Violet
Periodic acid schiff stains glycogen what color
Red to violet
Dark discoloration of the lymph nodes due to carbon is
Anthracosis
Accumulation of coal can cause a lung disease called
Coal workers pneumoconiosis
Alkapotunuria is
Black urine causes by incomplete breakdown of tyrosine and phenylalanine
Hemosiderin is accumulation of
Iron
Accumulation of iron is
Hemosiderin
What stain is used to test for iron
Prussian blue stain
Prussian blue stain stain ——- to ——-
Blue to iron
Hemosiderin is is usually occurs at what organ
Bone marrow
Soles
Lymph nodes
Excess break down of heme can lead to
And why
Jaundice
Because
Heme breakdown causes porphyrin to be converted to bilirubin
Jaundice is a characteristic of
Accumulation of bilirubin
Dystrophic calcification is
Accumulation of calcium in dead cells or tissue
Serum calcium level is normal in the body in dystrophic calcification
Metastatic calcification is
Accumulation of calcium in normal body tissue
Hypercalcemia is present
Stain uses for calcium are
Heamotoxylin and eosin
And
Von kossa stain
Von kossa stain stains calcium
Black
Von kossa stain
Stain for calcium
Gives it a black deposit
H&E stain gives calcium a
Basophillic granular amorphous appearance
After a fixed number of division all cells become arrested at a phase called
Replicative senescence
