interstitial lung disease

Question 1

What is pulmonary fibrosis

Answer 1

scarring of parenchyma

Question 2

What is airspace

Answer 2

alveolar disease

Question 3

What is included with airspace

Answer 3

Diseases that fill alveoli with fluid
-pneumonia
-edema
-hemorrhage
-aspiration
-sarcoidosis
-lymphoma

Question 4

How will alveolar disease look on imaging

Answer 4

fluffy

Question 5

What is interstitial disease

Answer 5

infiltrative disease leading to fibrosis of the lungs

Question 6

What is the most common type of pulmonary fibrosis

Answer 6

idiopathic

Question 7

What cells are effected with idiopathic pulmonary fibrosis

Answer 7

Loss of Type 1 and overgrowth of type 2 which impairs the repairing/growth of damaged cells

Question 8

What is pneumoconiosis

Answer 8

pulmonary fibrosis associated with chronic exposure to inorganic dust particles

Question 9

What cause pneumoconiosis

Answer 9

silica
asbestos
coal

Question 10

What are in the lung is effected with pneumoconiosis

Answer 10

scarring of the alveolocapillary membrane

Question 11

What classifications must be met to be diagnosed with pneumoconiosis

Answer 11

known exposure of offending agent

must have latent period

exclusion of other causes

exam/symptoms/imaging consistent with disease

Question 12

Where is coal workers pneumonia most common

Answer 12

KY
WV
VA

Question 13

What is the pathophys for coal miners lung

Answer 13

coal dust enters the lung
macrophages attack particles
cytokine release
nodules form
bronchioles dilate
airways change shape
obstruction

Question 14

Where do the fibrotic areas form with coal miners lung

Answer 14

where the most coal dust enters

Question 15

Where are black masses found with coal miners lung

Answer 15

upper, posterior lung field

Question 16

How will coal miners lung present

Answer 16

Melanoptysis
pulmonary HTN
Progressive dyspnea

Question 17

What is silicosis

Answer 17

Occupational lung disease associated with crystalline silica

Question 18

What is acute silicosis

Answer 18

develops within a few weeks after a few years of exposure

Question 19

What is accelerated silicosis

Answer 19

begins 5-10 years after significant exposure

Question 20

What is chronic silicosis

Answer 20

innumerable round opacities noted on imaging

Question 21

Where does silica dust settle with silicosis

Answer 21

terminal bronchioles and alveoli

Question 22

What is the pathophys with silicosis

Answer 22

-toxin inhaled
-macrophages activated
-Cytokine release
-Oxygen radicals form which directly -damage macrophages
-fibrosis occurs
-type 2 cells broken down

Question 23

What disease is commonly found with silicosis

Answer 23

TB

Question 24

What is the progression of silicosis

Answer 24

pulmonary fibrosis
Lung cancer
Mesothelioma

Question 25

What is sarcoidosis

Answer 25

granulomatous disease makes by accumulation of T lymphocytes and phagocytes

Question 26

What epigenetic trigger occurs with sarcoidosis

Answer 26

HLA

Question 27

What type of granuloma occurs with sarcoidosis

Answer 27

Non-caseating

Question 28

If a granuloma forms outside the lungs what can occur

Answer 28

Meningitis Uveitis Restrictive cariomyopathy hepatosplenomegaly arthralgias erythema nodosum

Question 29

What is the most common subtype of hypersensitivity pneumonitis

Answer 29

Farmers lung

Question 30

Where are hypersensitivity pneumonitis

Answer 30

Humid areas may be seasonal exposure to fungi/mold/yeast etc

Question 31

Who is bird fanciers lung seen in

Answer 31

pigeon breeders *associated with handling bird stool or material on feathers