Interstitial lung disease

Question 1

Worst survival on lung txp waiting list

Answer 1

IPF / UIP - median survival after dx is 3.8y

Question 2

Don’t use steroids in this ILD

Answer 2

IPF / UIP

Question 3

Men over 50 ILD

Answer 3

IPF /UIP

Question 4

Non uniform / patchy histology ILD

Answer 4

IPF / UIP

Question 5

Tx for IPF / UIP

Answer 5

Pirfenidone and nintedanib slow FVC decline by 50% over one year of therapy

Question 6

UIP is also called

Answer 6

IPF: Male over 50, bad prognosis, don’t use steroids; “patchy” histology

Question 7

ILD with female predominance

Answer 7

NSIP

Question 8

ILD with uniform histology

Answer 8

NSIP

Question 9

ILD a/w connective tissue disorders

Answer 9

NSIP

Question 10

Initial therapy for NSIP

Answer 10

Steroids are initial therapy; may respond to rituximab and cyclophosphamide

Question 11

5y survival for NSIP

Answer 11

80% (better than IPF/UIP, so biopsy is essential)

Question 12

Cellular subtype of NSIP impacts prognosis how?

Answer 12

Protective

Question 13

ILD in nonsmokers 50-60yo

Answer 13

Cryptogenic organizing pneumonia (BOOP)

Question 14

Nonsmoker 55yo p/w flu-like symptoms and progressive dyspnea, dx with ILD. What type?

Answer 14

Cryptogenic organizing pneumonia (BOOP)

Question 15

M/F relationship in Cryptogenic organizing pneumonia

Answer 15

Equivalent

Question 16

52 F p/w progressive dyspnea. Biopsy shows: Chronic alveolar inflammation with buds of granulation tissue within bronchioles and alveoli

Answer 16

Cryptogenic organizing pneumonia (formerly BOOP)