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Resp > Interstitial Lung disease * > Flashcards

Interstitial Lung disease * Flashcards

1
Q

Granulomatous ILD

A

Sarcoidosis

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2
Q

Inhalational ILD

A

Hypersensitivity Pneumonitis

Pneumoconiosis (Occupational)

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3
Q

Idiopathic ILD

A

Pulmonary Fibrosis (MC)

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4
Q

Connective Tissue ILD

A

RA

Scleroderma

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5
Q

What is the MC ILD

A

Pulmonary Fibrosis

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6
Q

What are the RF for Pulmonary Fibrosis

A

Old male smokers
Occupational
Methotrexate user
EBV/CMV

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7
Q

What are the presentations of Pulmonary fibrosis

A

Exertional dyspnoae

Dry cough

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8
Q

What is the pathology of pulmonary fibrosis

A

Progressive lung scarring = T1 resp fail

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9
Q

What type of resp fail is pulmonary fibrosis

A

T1 (Fibrosis so improper filling)

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10
Q

How is Pulmonary fibrosis Investigated

A

Spirometry = Restriction
FEV1/FVC >0.7 w/
High Resolution CT = Ground glass lungs and traction bronchiectasia

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11
Q

How would you describe the image of Pulmonary fibrosis on a chest CT

A

Ground glass

Traction Bronchiectasia

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12
Q

How would you manage Pulmonary Fibrosis

A

Smoking cessation and Vaccine
Pirfenidone / Nintendinir
Lung transplant

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13
Q

What medication can be given for pulmonary fibrosis

A

Pirfenidone / Nintendinir

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14
Q

What is Pneumoconiosis

A

Occupational ILD

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15
Q

What are the two causatives of Pneumoconiosis

A

Silicosis

Abestosis

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16
Q

How can silicosis cause pneumoconiosis

A

Inhale silicon dioxide = eggshell calcification @ hilar lymph nodes

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17
Q

How can Asbestosis cause pneumoconiosis

A

Inhale asbestos = affected pleura = Mesothelioma (T1 RF)

18
Q

What is sarcoidosis

A

Idiopathic granulomatous ILD

19
Q

What are the RF for sarcoidosis

A

Women
20-40
Afro caribbean

20
Q

How does a patient present w/ Sarcoidosis

A

Fever and fatigue
Dry cough and dyspnoea
Uveitis
Lupus Pemio (Blue/red nodules on nose/cheeks)

21
Q

What is Lupus Pemio

A

Blue-red nodules on nose and cheeks

-Found in Sarcoidosis

22
Q

How is Sarcoidosis investigated

A

CXR =Bilateral hilar adenopathy and Pulmonary infiltrates
Biopsy = Non caseating granuloma
Raised Calcium and Serum ACE(Granuloma)

23
Q

How is Sarcoidosis managed

A

Corticosteroids if Symptomatic

24
Q

What is Hypersensitivity Pneumonitis

A 
T3 Hypersensitivity  (Antibody to antigen complex deposition)
@lung tissue causing Immune hyperresponse
25
Q

What are the RF for HS Pneumonitis

A

Occupation (Farming and bird keeping)

26
Q

What causes farmer’s lung Pneumonitis

A

Mouldy Hay

27
Q

What causes Pigeon Fancier’s lung in pneumonitis

A

Avian protein in bird droppings

28
Q

How can HS Pneumonitis be managed

A

Removing the allergen

29
Q

What is Good pasture’s Syndome

A

T2 Autoimmune HS reaction caused by Anti GBM

30
Q

What is the pathology of GoodPastures

A

Anti GBM attacks lungs (fibrosis) and kidneys (GN)

31
Q

How is Good Pastures Investigated

A

Lung and kidney biopsy for damage and IgA Deposition

Anti GBM positive

32
Q

What antibody is produced in Good pastures

A

Anti GBM

33
Q

How is Good pastures managed

A

Supportive
Corticosteroids
Plasma exchange (remove Anti GBM)

34
Q

What is Wegener’s GPA

A

Granulomatosis w/ Polyangitis

-Small/Medium cell Vasculitis affecting ELK (ENT, Lung and Kidney)

35
Q

What are the presentations of Wegener’s

A

ENT - Saddle nose and ear infection
Lungs = Diffuse Alveolar haemorrhage = Haemoptysia
Kidney = GN = Haematuria

36
Q

How does Wegener’s affect the ENT

A

Saddle shaped nose and ear infection

37
Q

How does Wegener’s affect the kidney

A

GN causing haematuria

38
Q

How does Wegener’s affect the Lungs

A

Diffuse alveolar haemorrhage = Haemoptysia

39
Q

What is the diagnostic serology for Wegener’s EGPA

A

cANCA

40
Q

How can the serology of Wegeners GPA and MPA be differentiated

A

wGPA =cANCA

MPA = pANCA

41
Q

How is Wegener’s GPA Treated

A

Corticosteroids

Rituximab for immunosuppressed

Resp (14 decks)

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