Internal Medicine: Nephro and Gastro

Question 1

What is the clinical indication of Deferoxamine?

Answer 1

Hemachromatosis when phlebotomy is contraindicated

Question 2

When is Deferoxamine contraindicated?

Answer 2

When patients with hemachromatosis also have cardiomyopathy and or anaemia

Question 3

What is the mechanism of action of Deferoxamine?

Answer 3

Deferoxamine binds to free iron in the blood enhancing its elimination in the urine

Question 4

What is the treatment of HH?

Answer 4

Phlebotomy

Deferoxamine - in patients in which have cardiomyopathy or anaemia (where phlebotomy is contraindicated)

Question 5

What drugs are used in the treatment of Wilson’s disease?

Answer 5

penicillamine
trientine
zinc
tetrathiomolybate

Question 6

What is the best pharmacotherapy for hepatic presentations in Wilson’s disease?

Answer 6

Trientine and Zinc

Question 7

What are the neurological manifestations of Wilson’s disease best treated with?

Answer 7

Zinc

Question 8

What is the treatment in autoimmune hepatitis?

Answer 8

Corticosteroids and azathioprine

Question 9

What is the clinical indication of pantoprazole?

Answer 9

bleeding in peptic ulcers

Question 10

What is the mechanism of action of pantoprazole?

Answer 10

It binds to and inhibits the H/K ATPase found on Parietal cells

Question 11

How is pantoprazole administered?

Answer 11

IV continuous drip