Interleukins Flashcards
IL-1 Source
Macrophage
Lymphocytes
endothelium
fibroblasts
astrocytes
IL 1 target cell
T cells
B cells
macrophages
endothelium
tissue cells
IL- 1 effect
Lymphocyte activation
leukocyte endothelial adhesion
fever
regulates sleep
IL 2 source
T cells
IL 2 target cell
T cells
IL 2 effect
T cell growth factor
IL 3 source
T cells
IL 3 target
bone marrow cells
IL 3 function
stimulates bone marrow growth
IL 4 source
T cells
IL 4 target
B and T cells
IL 4 effect
B cell growth factor
IL 5 source
T cells
IL 5 target
B cells
IL 5 effect
B cell growth factor
IL 6 source
T and B cells
macrophages
fibroblasts
IL 6 target cells
B cells and hepatocytes
IL 6 effect
B cell differentiation and synthesis of acute phase reactants
IL 7 source
lymphocytes
IL 7 target
B and T cells
IL 7 stimulates proliferation of immature cells
IL 8 source
T cells
macrophages
IL 8 target
granulocytes
endothelium
IL 8 effect
stimulates the activity of neutrophils
acts as chemotaxin
inhibitor of endothelial cell leukocyte adhesion
IL 9 source
T cells
IL 9 target
T cells
IL 9 effect
T cell and mast cell growth enhancement
IL 10 source
T cells
IL 10 target
macrophage
IL 10 effect
suppresses development of T cells subpopulations by inhibition of macrophage IL 12 production
IL 11 source
bone marrow stromal cells
IL 11 target
hepatocytes
IL 11 effect
induces synthesis of acute phase proteins
IL 12 source
macrophage
IL 12 target
T cells
IL 12 effect
enhances B cells expression of IFN-y during T cell activation
stimulates lymphocyte subpopulation (NK cells)
