Interactions

Question 1

What are the preferred statins to be prescribed to a person taking warfarin?

Answer 1

ATORVASTATIN or PRAVASTATIN

Question 2

Which of the statins are mainly CYP3A4 metabolised?

Answer 2

SIMVASTATIN AND ATORVASTATIN

Hence these two have the most interactions out of their class.

Question 3

What can the combination of ezetemibe and fenofibrate potentially cause?

Answer 3

GALLSTONES.

(Additive increases in cholesterol excretion into the bile due to both can increase the risk of cholelithiasis).

Question 4

Which statins do antacids need to spaced TWO hours away from?

Answer 4

Rosuvastatin… an antacid may decrease rosuvastatin concentration. Give antacid TWO hours after rosuvastatin.

Question 5

What medications interact with cyproheptadine (Periactin)?

Answer 5

SSRIs or MAOIs

Cyproheptadine antagonises serotonin, so may reduce the antidepressant effect of SSRI’s

Question 6

Which two antidepressants require a longer washout period of at least 14 days?

Answer 6

Fluoxetine
Vortioxetine (brintellix)

Question 7

Which two statins have the MOST interactions?

Answer 7

Atorvastatin and Simvastatin

Question 8

What is the effect of using both a tetracycline and a retinoid?

Answer 8

the combination, for example doxycyline and isotretinoin can cause intracranial hypertension

Question 9

What drug class needs is contraindicated with phosphodiesterase-5 inhibitors and if taken together needs to have their doses separated ?

Answer 9

ANY NITRATE!! - increases the risk of hypotension or MI.
Wait at least 12 hours with avanil
Wait at least 24 hours with sildenafil or vardenafil
and 48 hours with radalafil