Intense IPM

Question 1

What does TLR-2 detect?

Answer 1

TB
Lipoteichoic acid

Question 2

What does TLR-4 detect?

Answer 2

LPS on surface of Gram-ve

Question 3

Which TLRs are intracellular?

Answer 3

TLR 3, 7, 8, 9

Question 4

What are TLRs expressed on?

Answer 4

Innate immune cells

Question 5

What do all TLRs contain?

Answer 5

Leucine-rich repeats

Question 6

MOA of beta lactem

Answer 6

Inhibit peptidoglycan layer in cell wall

Question 7

What don’t have a cell wall?
(and ∴ are vulnerable to beta-lactems)

Answer 7

Mycoplasma

Question 8

What can turn into macrophages?
Where?

Answer 8

Monocytes
Alveoli (not just in alveoli tho)

Question 9

What are polymyxins?

Answer 9

Abx that target cell membrane of Gram -ve

Question 10

What are 50s ribosomal subunits targeted by?

Answer 10

Macrolides

Question 11

What does the S in 50s, 30s mean?

Answer 11

S = unit of measurement
Measures how fast cells sediment after ultracentrifugation

Question 12

What does TLR5 detect?

Answer 12

Flagellin

Question 13

What does TLR9 detect?

Answer 13

Non-methylated nucleotide motifs

Question 14

What does TLR7 detect?

Answer 14

Single stranded RNA

Question 15

What does TLR-10 detect?

Answer 15

Listeria
Influenzae A

Question 16

Where is TRL-11 found?

Answer 16

Protein found in rats and mice

Question 17

Lymphoctyes

Answer 17

B and T cells

Question 18

What are astrocytes?
Where are they never found?

Answer 18

Glial cells
help form BBB
never found in CSF

Question 19

MC organism causing Traveller’s diarrhoea

Answer 19

Enterotoxigenic E. Coli

Question 20

How does shigella present?

Answer 20

Bloody diarrhoea 48-72 hours after ingesting toxin

Question 21

Tx Traveller’s diarrhoea

Answer 21

Quinolones

Question 22

How does giardia present?

Answer 22

Abdo pain
Bloating
Non-bloody diarrhoea

Question 23

How long does Giardia incubate for?

Answer 23

> 7 days

Question 24

How long after infection does salmonella present?

Answer 24

12-24 hours