Integument And Immune Flashcards
The ___ contains the blood supply to the skin and the specialized cells whereas the ____ contains keratinocytesp
Dermis
Epidermis
Secrete oil onto the surface of the skin to keep its pH relatively acidic and decreases bacterial growth
Sebaceous glands
Keratinocytes differentiate into ___ : waterproof cells often replaced and sloughed off
Corneocytes
2 major types of immunity ?
Humoral: antibody production
Cell-mediated : cells combatting fungal and viral infections
The released chemical from white blood cells activating the immune system
Histamine
Histamine function?
Dilates and increases the permeability of blood vessels
Kills temperature dependent pathogens and speeds up the healing process
Fever
Reservoirs of white blood cells and filters for lymph, removing antigen presenting cells and foreign matter and activating the immune system when necessary
Lymph nodes and spleen
First responders Attracted to cytokines Attract WBC Attack bacteria Main component of pus
Neutrophils
Immune responses Less common Allergic/asthmatic responses React to ectoparasites Related to mast cells Histamine Heparin
Basophils
Parasites living on the surface of skin such as fleas and ticks. Trigger allergic reactions
Ectoparasites
Release histamine Stimulate blood vessel dilation Indicate Helminths (intercellular parasitic worms ) Allergic responses Phagocytes
Eosinophils
Large long lived immune cells that can differentiate into macrophages and dendritic cells
Monocytes
Phagocytize dead cells and pathogens. Antigens of ingested pathogens are presented On outside to mount a specific immune response
Macrophages
More focused on processing antigens and presenting them to other immune cells.found where contact with external environment is common
Dendritic cells
Specific immunity. Becomes reactive to only one random antigen type, presented by a major histocompatibility protein complex. Enough created to defend body against nearly any pathogen
T cells
Cytotoxic T cells. (Cd8 + T cells )
Respond to?
Function ?
MHC I
Cells infected with viruses or developing tumors
Destroy these cells
T helper cells (cd4+)
Respond to?
Function?
MHC II
Released cytokines and stimulate immune response
Natural killer T cells
Respond to?
Other antigens present by other types of cells than Tc and Th
Tone down T cell response to self cells or following an infection
Regulatory or suppressor T cells
T cells
Develop?
Mature ?
Bone marrow
Thymus
Low levels of T cells , subject to infection
Aids
B lymphocytes
Development ?
Mature?
Both In bone marrow
Expressed by B cells , provide specific targeted responses to a given antigen
Antibodies / immunoglobulins
