Integument Flashcards
Integument functions (5)
protections, thermoregulation, sensory organ, metabolic (Vitamin D synthesis), excretion (water, salt, and nitrogenous waste)
Generally has 3 types
epidermis, dermis, hypodermis
thick skin is usually found on
palms of hand and soles of feet
thick skin has no
hair follicles
thin skin is found on
skin other than palms and soles
thin skin has
hair follicles and thinner epidermis
epidermis has stratified squamous epithelial cells called
keratinocytes (produce keratin)
Types of epidermis (5) all start with stratum
basale, spinosum, granulosum, lucidum, corneum
stratum basale has numerous intermediate filaments called _; _ bind cells to basal lamina
tonofilaments
hemidesmosomes
stratum spinosum has fibrillar protein called _ that aggregates to form _
cytokeratin
tonofibrils
stratum basale and spinosum also have
mitotic figures
stratum granulosum cytoplasm has basophilic _
keratohyaline granules
stratum granulosum cells also have oval or rod-like _
lamellar granules
lamellar granules are formed by lipid bilayers which fuse with cell membranes and _
discharge contents into intercellular spaces of the S. granulosum
the product of the lamellar granules and its discharge contents is
glycolipid called acylglucoceramide
purpose of acylglucoceramide
penetration barrier to foreign materials and to maintain hydration of the body
stratum lucidum is only in
thick skin
stratum lucidum has no organelles or nuclei evident; cells contain eleidin, which is a
transformation product that becomes keratin
stratum corneum has what kind of cells
dead flattened cells called squames
if epidermis is injured, surrounding _ cells _ and _ to cover the wound
basal
migrate
divide
what is needed for proper skin healing
retinol (vitamin A) because it’s needed for keratinocyte differentiation
first degree burns extend to
S. lucidum
2nd degree burns extend to
S. basale
3rd degree burns extend to
dermis
lipids from lamellar bodies are linked to protein in the cell membrane called
involucrin
_ protein aggregates keratin filaments
filaggrin
pigment producing cells of S. basale derived from neural crest
melanocytes
melanocytes distribute _ to other cells and hair via _
melanin
cytocrine secretion
melanin formation occurs within
melanosomes (Derived from Golgi)
what enzyme is needed for melanin synthesis
tyrosinase
lack of cortisol from the adrenal cortex causes overproduction of ACTH leading to
Addison’s disease (increased skin pigmentation)
(likely unnecessary) melanin is produced by oxidation of _ to _ and then transformed into melanin
tyrosine
dihydroxyphenylalanine (DOPA)
melanocyte cytoplasm is _ than neighboring keratinocytes
less dense