Inotropes and vasopressors Flashcards
The following drugs act on α1-receptors
T/F
Dobutamine
True. Dobutamine acts on α- and β-adrenergic receptors, but has a much weaker α action.
The following drugs act on α1-receptors
T/F
Ephidrine
True. Ephedrine acts on α- and β-adrenergic receptors.
The following drugs act on α1-receptors
T/F
Adrenaline
True. Adrenaline acts on α- and β-adrenergic receptors.
The following drugs act on α1-receptors
T/F
Isoprenaline
False. Isoprenaline is a β-receptor agonist.
The following drugs act on α1-receptors
T/F
Levosimendan
False. Levosimendan improves contractility by increasing myocardial sensitivity to calcium, but it also relaxes vascular smooth muscle by opening ATP-sensitive potassium channels causing peripheral vasodilatation.
The following have some positive inotropic action
T/F
Dopamine
True. Dopamine has positive inotropic properties via β-adrenergic action.
The following have some positive inotropic action
T/F
Potassium
False
The following have some positive inotropic action
T/F
Phenylephrine
False. Phenylephrine is a pure α-adrenergic agonist.
The following have some positive inotropic action
T/F
Theophylline
True. Theophylline is a non-selective phosphodiesterase inhibitor and works in a similar way to milrinone and enoximone.
The following have some positive inotropic action
T/F
Glucagon
True. Glucagon works via Gs-protein receptors which increase cAMP levels. It is only rarely used in the management of β-blocker overdose.
T/F
Ephidrine Causes increased noradrenaline release from nerve terminals
True Ephedrine has mixed α- and β- adrenergic action. It also increases noradrenaline release from nerve endings and inhibits monoamine oxidase from breaking down noradrenaline
T/F
Ephidrine Displays tachyphylaxis
True. Tachyphylaxis occurs as noradrenaline stores are depleted
T/F
Ephidrine Increases systemic vascular resistance
True
T/F
Ephidrine Crosses the placenta
True
T/F
Ephidrine Has bronchoconstrictor activity
False α-adrenergic action causes an increase in systemic vascular resistance whilst β2 action causes bronchodilatation
The following drugs work via G-protein receptors:
Dopamine
True. Dopamine works at α- and β- receptors which are both G-protein coupled.
The following drugs work via G-protein receptors:
Levosimendan
False. Levosimenden binds to Troponin C.
The following drugs work via G-protein receptors:
Dopexamine
True. Dopexamine works at α- and β- receptors which are both G-protein coupled.
The following drugs work via G-protein receptors:
Milrinone
False. Milronone is a selective phosphodiesterase III inhibitor.
The following drugs work via G-protein receptors:
Digoxin
False. Digoxin works by inhibiting the sodium-potassium ATPase pump.
T/F; Dobutamine Is structurally similar to dopamine
False
Dobutamine is structurally similar to isoprenaline
T/F; Dobutamine Activates adeylate cylcase
True
works via Gs-protein receptors that activate adenylate cyclase
T/F; Dobutamine Has a selective action on β-adrenoreceptors
False
It has weak action on α-receptors
T/F; Dobutamine Has a half-life of 2 minutes
True
T/F; Dobutamine Increases the left ventricular end-diastolic pressure
False
It decreases left ventricular end-diastolic pressure via its action on peripheral β2-receptors. β2-linked peripheral vasodilatation reduces venous return
