Cram Flashcards
1
Q
Thiopental
Chemical composition
A
Thiobarbituate
2
Q
Thiopental
Dose
A
3-7 mg/kg
3
Q
Thiopental
pKa
A
7.6
4
Q
Thiopental
pH
A
10.5
5
Q
Thiopental
Volume of distribution
A
2.5 L/kg
6
Q
Thiopental
protein binding
A
80%
7
Q
Propofol
Chemical composition
A
2,6 Diisopropylphenol
8
Q
Propofol
dose
A
1-2 mg/kg
9
Q
Propofol
pKa
A
11.0
10
Q
Propofol
pH
A
6-8.5
11
Q
Propofol
Protien binding
A
98%
12
Q
Ketamine
Chemical compostion
A
Phencyclidine derivative
13
Q
Ketamine
dose
A
1-2mg/kg IV
5-10 mg/kg IM
14
Q
Ketamine
pKa
A
7.5
15
Q
Ketamine
pH
A
3.5-5.5
16
Q
Ketamine
protein binding
A
25%
17
Q
Etomidate
Chemical composition
A
Imidazole ester
18
Q
Etomidate
Dose
A
0.3mg/kg
19
Q
Etomidate
pKa
A
4.0
20
Q
Etomidate
pH
A
8.1
21
Q
Etomidate
volume of distribution
A
3.0 L/kg
22
Q
Etomidate
MOA
A
stimulates GABA
23
Q
Ketamine
MOA
A
Inhibits NMDA
24
Q
Propofol
MOA
A
Stimulates GABA, inhibits NMDA
25
Thiopental
| MOA
increases duration of GABAa opening
26
Which IV induction agents have active metabolites
Thiopental, Ketamine
27
Which IV induction agents have inactive metabolites
Propofol, etomodate
28
Which IV induction agent is not racemic
Propofol
29
Metabolism of thiopentone
Oxidation
30
Metabolism of propofol
Gluronidation and hydroxylation
31
metabolism of ketamine
N-demethylation and hydroylation
32
Metabolism of etomidate
Plasma and hepatic esterases
33
```
Elimination rate (hours)
Etomidate
ketamine
Propofol
thiopental
```
1-4
2
5-12
6-15
34
```
Clearance ml/kg/min
Etomidate
ketamine
Propofol
thiopental
```
10-20
17
30-60
3.5
35
Which IV induction agents cause pain on injection
propofol, etomidate
36
Which local anaesthetics are esters (-COO-)
procaine
| amethocaine
37
Which local anaesthetics are amides (-NHCO-)
lidocaine, prilocaine, bupivicaine, ropivicaine, mepivicaine
38
short acting local anaesthetic (and protein binding)
procaine (6%)
39
medium acting local anaesthetic (and protein binding)
lidocaine (70%), prilocaine (55%), mepivicaine (77%)
40
long acting local anaesthetic (and protein binding)
amethocaine (75%), bupivicaine (95%), ropivicaine (94%)
41
slow onset local anaesthetic (and pKa)
Esters and mepivicaine (7.6)
42
Fast onset local anaesthetic (and pKa)
lidocaine (7.9), prilocaine (7.7)
43
Max dose lidocaine
3 mg/kg
44
Max dose prilocaine
6mg/kg
45
Max dose bupivicaine
2 mg/kg
46
Max dose ropivicaine
3.5mg/kg
