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FRCA Pharmacology > Cram > Flashcards

Cram Flashcards

1
Q

Thiopental

Chemical composition

A

Thiobarbituate

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2
Q

Thiopental

Dose

A

3-7 mg/kg

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3
Q

Thiopental

pKa

A

7.6

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4
Q

Thiopental

pH

A

10.5

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5
Q

Thiopental

Volume of distribution

A

2.5 L/kg

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6
Q

Thiopental

protein binding

A

80%

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7
Q

Propofol

Chemical composition

A

2,6 Diisopropylphenol

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8
Q

Propofol

dose

A

1-2 mg/kg

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9
Q

Propofol

pKa

A

11.0

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10
Q

Propofol

pH

A

6-8.5

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11
Q

Propofol

Protien binding

A

98%

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12
Q

Ketamine

Chemical compostion

A

Phencyclidine derivative

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13
Q

Ketamine

dose

A

1-2mg/kg IV

5-10 mg/kg IM

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14
Q

Ketamine

pKa

A

7.5

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15
Q

Ketamine

pH

A

3.5-5.5

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16
Q

Ketamine

protein binding

A

25%

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17
Q

Etomidate

Chemical composition

A

Imidazole ester

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18
Q

Etomidate

Dose

A

0.3mg/kg

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19
Q

Etomidate

pKa

A

4.0

20
Q

Etomidate

pH

A

8.1

21
Q

Etomidate

volume of distribution

A

3.0 L/kg

22
Q

Etomidate

MOA

A

stimulates GABA

23
Q

Ketamine

MOA

A

Inhibits NMDA

24
Q

Propofol

MOA

A

Stimulates GABA, inhibits NMDA

25
Q

Thiopental

MOA

A

increases duration of GABAa opening

26
Q

Which IV induction agents have active metabolites

A

Thiopental, Ketamine

27
Q

Which IV induction agents have inactive metabolites

A

Propofol, etomodate

28
Q

Which IV induction agent is not racemic

A

Propofol

29
Q

Metabolism of thiopentone

A

Oxidation

30
Q

Metabolism of propofol

A

Gluronidation and hydroxylation

31
Q

metabolism of ketamine

A

N-demethylation and hydroylation

32
Q

Metabolism of etomidate

A

Plasma and hepatic esterases

33
Q 
Elimination rate (hours)
Etomidate
ketamine
Propofol
thiopental
A

1-4
2
5-12
6-15

34
Q 
Clearance ml/kg/min
Etomidate
ketamine
Propofol
thiopental
A

10-20
17
30-60
3.5

35
Q

Which IV induction agents cause pain on injection

A

propofol, etomidate

36
Q

Which local anaesthetics are esters (-COO-)

A

procaine

amethocaine

37
Q

Which local anaesthetics are amides (-NHCO-)

A

lidocaine, prilocaine, bupivicaine, ropivicaine, mepivicaine

38
Q

short acting local anaesthetic (and protein binding)

A

procaine (6%)

39
Q

medium acting local anaesthetic (and protein binding)

A

lidocaine (70%), prilocaine (55%), mepivicaine (77%)

40
Q

long acting local anaesthetic (and protein binding)

A

amethocaine (75%), bupivicaine (95%), ropivicaine (94%)

41
Q

slow onset local anaesthetic (and pKa)

A

Esters and mepivicaine (7.6)

42
Q

Fast onset local anaesthetic (and pKa)

A

lidocaine (7.9), prilocaine (7.7)

43
Q

Max dose lidocaine

A

3 mg/kg

44
Q

Max dose prilocaine

A

6mg/kg

45
Q

Max dose bupivicaine

A

2 mg/kg

46
Q

Max dose ropivicaine

A

3.5mg/kg

FRCA Pharmacology (13 decks)

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