Innate Immunity Flashcards
cell adhesion molecules
mucins and selectins
integrins
mucins
on all cells such as WBCs and endothelial
selectins
L-selectin = WBCs
E-selectin, P-selectin = endothelial
what are mucins/selectins?
- glycoproteins on endothelial and immune cells
- constantly expressed and activated
- weak binding to one another
= slow each other down if rolling along fast
= like scotch tape; stronger when more
integrins
inactive proteins in alpha & beta subunits
tight binding
in natural state = NOT active; ned to dimerize to be active
examples of integrins
CD11a, CD18
Ig Superfamily CAMs
bind integrin dimers; tight binding
= ICAM-1, ICAM-2, ICAM-3, VCAM-1
important cell adhesion molecules (CAMS)
APC = LFA-3 and T cell = CD2
APC = ICAM-1 and LFA-1
T or F. LFA is only on lymphs
F! on many WBCs
LFA-1 is made up of…
CD11a and CD18
TNF
- pro-inflammatory (chemoattractant, increases adhesion, and primes macrophages)
- produced by activated macrophages and other cells
- induces fever
- activates immune cells through TNFR1 = 3 pathways
- activates epithelial, endothelial = proliferation for wound healing
- can induce apoptosis
IFN-y
- secreted by Th1, Tc, NK, macs
- activated immune cells = cause them to express MHC I/II, CAMs, receptors, lysosome/NOS, can slow down machinery/reduce anti-viral properties
T or F. Phagocytosis of viruses happen
T! Antibodies can coat viruses to neutralize them
Can also coat viruses with complement so macrophages can phagocytose them
T or F. Complement can lyse enveloped viruses
T! Through MAC
Can also bind C3 for opsonization or complement can block receptors that virus needs to infect cell
NK cells recognize this
absence of MHC I = foreign!!! so now must act to remove it
virus-infeced cells produce these cytokines to activate NK cells
IFN-a and IFN-B
