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Pharm Exam 3 > Injectable Anesthesia > Flashcards

Injectable Anesthesia Flashcards

1
Q

Therapeutic index of etomidate

A

16 (high)

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2
Q

Therapeutic index of ketamine

A

High

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3
Q

Therapeutic index of Alfaxalone

A

> 20 (high)

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4
Q

Therapeutic index of Propofol

A

3 (low)

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5
Q

Therapeutic index of Thiopental

A

5 (low)

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6
Q

Therapeutic index =

A

LD50/ED50

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7
Q

Time of awakening is based on what phase? (Elimination or redistribution)

A

Redistribution

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8
Q

Context sensitive half life

A

Time it takes to wake up once CRI is discontinued

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9
Q

Drop in serum protein will lead to _____ in free portion of anesthetic of analgesic drug

A

Increase

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10
Q

Drop in serum protein will _____ drug effect and side effects

A

Increase

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11
Q

Mechanism of action for barbiturates (thiopental)

A

GABA

Acts on barbiturate site and GABA site to open receptor so Cl can enter cell (cell becomes negative and lazy)

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12
Q

Properties of Propofol

A

Short acting/fast clearance
Recovery due to redistribution
Smooth induction and recovery
Short context sensitive half life

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13
Q

Mechanism of action for propofol

A

GABA

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14
Q

Propofol good for patients with liver problems?

A

Yes

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15
Q

Complications of propofol

A

HIGH FAT VEHICLE

Vehicle composed of soy bean oil and egg lecithin ->
Bacterial growth
Fat embolisation
High plasma triglyceride

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16
Q

Etomidate good for use in patients with ________

A

Heart problems

Also good for respiratory and ICP

17
Q

Etomidate adverse effects

A

Adrenal suppression

Decreases cortisol, corticosterone, aldosterone…… prolonged suppression leads to death

18
Q

Ketamine is the only anesthesic drug with _______ properties

A

Analgesic

NDMA receptor

19
Q

What is the great thing about Telazol?

A

Can be concentrated as much as you want

20
Q

Alfaxalone

A

New drug
Works on GABA
Safe

Pharm Exam 3 (6 decks)

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