inhibitors of nucleic acid synthesis Flashcards
what is the MOA of sulfonamids
inhibit the first step of bacterial folate synthesis
inhibit dihydropteroate synthase
and humans DONT have this enzyme so dats great
sulfonamides are highly protein bound, what does this mean for da wittle babies
that it can cause kernictus
what drugs can cause steven johnson syndrome
sulfonamides
gimmie some things that can cause hemolysis in peeps with G6PD deficiency
malaria drugs
TB drugs
sulfonamides
flava beans (what are these?)
how do trimethoprim and pyrimethamine work? so what are worried about?
inhibit dihydrofolate reductase
note: humans also have this enzyme so these drugs will have cancer drug like SEs (bone marrow suppression)
what are the 2 classical drug combos to know in reference to nucleic acid synthesis inhibitors
trimethoprim-sulfamethoxazole (TMP SHX): bactram
pyrimethamine-sulfadiazine
what drug combo is the DOC for nocardia
trimethoprim-sulfamethoxazole (TMP SHX): bactram
what drug combo is used for P. jiroveci
trimethoprim-sulfamethoxazole (TMP SHX): bactram
what drug combo is used for T. gondii infection
pyrimethamine-sulfadiazine
what are the DIRECT inhibitors of nucleic acid synthesis
quinolones
what are some quinolones
“-floxacins”
norfloxacin
ciprofloxacin
ofloxacin
what is the MOA of quinolones
bactericidial
inhibit topoisomerase II and topoisomerase IV
gimmie some clinical uses of the quinolones
Urinary, skin and GI gram - infections, STDs
**note this includes pseudomonas
also moxi and levo good for resistant S pneumo
how are the quinolones excreted?
by the kidney
what about the quinolones are kinda like tetracyclines?
Iron & calcium limit quinolone absorption- this is like the chelating effects of tetracyclines
