Antimicrobials - principals Flashcards
Are antibiotics which inhibit the synthesis of the cell wall bacteriostatic or -cidal?
bactericidal
Which cell wall inhibitor is NOT a lactam?
vancomycin
What are some common neonatal infections?
ecoli, group B strep, listeria
What infection is likely to infect college students?
N meningitis
What are two infections that very common in the elderly?
listeria
S pneumoniae
If a person has a prosthetic, what are they particularly at risk for?
coagulase negative staph
What is the most common antibiotic allergy?
B lactam hypersensitivity allergy
-antibiotics are derived from fungus - cause immune system to be hypersensitive!!!
What antibiotic do you need to be extra careful with renal dysfunction?
aminoglycosides
How does an obese person affect the efficacy of a drug?
increases the volume of distribution
Enterococcus are intrinsically resistant to ____
pseudomonas are intrinsically resistant to _____
- cephalosporins
2. vancomycin
What method microbes are notorious for B lactamase production?
enterobacteriacae , particularly enterobacter
What is the notorious method of pseudomonas resistance?
porin channel mutation
What are the four factors of pharmacokinetics?
- absorption
- distribution
- metabolism
- elimination
Who has a thicker cell wall gram positive or gram negative?
gram positive
Tell me about the cell wall of gram positives?
alternating NAG and NAM connected by B1-4 linkages
-side chains attached to NAM
