Antifungals Flashcards
MOA of trizoles?
inhibit ergosterol synthesis by inhibiting 14 alpha sterol demethylase
What is posaconazole used to treat
prophylaxis of aspergillosis and candida in IC
what is voriconazole used to treat?
invasive aspergillosis
what is itraconazole used to treat
secondary treatment and prophylaxis of histo
what is fluconazole used to treat
thrush
secondary and prophylaxis of crypto
What is the main s/e of trizoles
liver abnormalities - measure the LFTs
what is an additional s/e of voriconazole
“shade pulled down on their vision”
V for vision
what is the MOA for amph B
generates pores in the PM
Is amph B cidal or static
cidal
are the trizoles cidal or static
static
what is the main s/e of amph B
nephrotoxicity
it WILL happen it is just a matter of time when
what is another s/e of amph B
acute infusion reaction - pre medicate with dihydraphenadine and acetaminophen
what form of amph B is more renal protective? what is the downside of this form
lipid soluble
it is very expensive
what is the MOA of the echinocandins
inhibit B 1,3 D glucan - inhibits ergosterol synthesis
what are the echinocandins
“fungins”
caspofungin, micafungin, anidulafungin
what are the echinocandins used to treat
candida and aspergillus
also used for empiric therapy
what are some negatives of echinocandin use
IV formulation only
expensive
how are the echinocandins eliminated?
hepatically
what is the MOA of flucytosine
uses fungal enzyme to convert to 5FU
inhibits DNA and RNA synthesis
what is flucytosine used to treat
crypto and candida used in combo with other drugs
quick resistance often develops however
what is the main s/e of flucytosine?
pancytopenia - think chemo drug!!!
