Inhibitors of Essential Metabolites

Question 1

Sulfamethoxazole/Trimethoprim Bactrim is effective against what kind of bacteria?

What is it not active against?

Answer 1

Gram Neg and Staph
2nd best PO coverage vs MRSA

Group A strep

Question 2

What is bactrim the drug of choice for?

What else can it be used for?3

Answer 2

Pneumocyctis pneumonia

UTI
OM
ABECB

Question 3

What is the mechanism of action for bactrim?

Answer 3

Inhibits folic acid synthesis therefore avoid in pregnancy/infants

Question 4

Nitrofurantion (Macrobid)
is only a treatment for what?

What bacteria does it cover?

Answer 4

Only for treatment and prevention of uncomplicated urinary tract infections (cystitis)

PO

Gram +, Gram - or enterococcus

Question 5

MOA for Nitrofurantion (Macrobid)?

Answer 5

Excreted in the urine where its active metabolites attack multiple bacterial sites

Question 6

S/E we have to watch other for with Nitrofurantion (Macrobid)?
2

Answer 6

Hypersensitivity pneumonitis and chronic pulmonary fibrosis