DNA or RNA Synthesis Inhibitors

Question 1

What are the types of DNA or RNA Synthesis Inhibitors?

3

Answer 1

Fluoroquinolones
Metronidazole (Flagyl)
Daptomysicn

Question 2

What are the 6 types of Fluoroquinolones?

Of the six which are the most commonly used?3

Answer 2

Ciprofolxacin* (Cipro)
Levofloxacin* (Levaquin)
Moxifloxacin* (Avelox)
Gemifloxacin (Factive)
Norfloxacin (Noroxin)
Oflaxacin (Floxin)

Question 3

Whats the specific MOA of fluroquinolones?

Answer 3

Inhibits DNA gyrase

Question 4

Major contraindications of fluroquinolones?

2

Answer 4

Pregnant females

Pts under 18 - interferes with articular cartilage

Question 5

What bacteria does Ciprofloxin cover?

Name specific bacteria?
5

Answer 5

BEST Gram neg coverage of all FQ

Enteric organisms!
H. Flu
Neisseria
Campylobacter
EXCELLENT VS PSEUDOMONAS

Question 6

What are the three diseases/infections that Cipro is typically used for?

Name 4 others?

Answer 6

UTI
Pyelonephritis
Gastroenteritis

PID
Malignant OE
Sinusitis
Gonococcal arthritis

Question 7

Norfloxacin and Levofloxacin differ from Cipro how?

2

Answer 7

Better activity vs gram Pos

Used for CAP. Works against Strep Pneumo. Cipro is not

Question 8

What is Norfloxacin and Levofloxacin typically used for?

Answer 8

Same as Cipro but also treats CAP

Question 9

Moxifloxacin differs from the other FQs how?

3

Answer 9

Best for

1. Gram Pos
2. Anaerobic
3. Atypical coverage

Question 10

What diseases/ infections is Moxifloxacin typcailly used for?
5

Answer 10

Resp:
CAP
Bronchitis
Sinusitis

Intraabdominal infections
Opthalamic and skin infections

Question 11

Ofloxicin (floxin) has the same coverage as the other FQs except for what?

Same with Gatifloxacin and Lomefloxacin

Answer 11

Enhanced coverage of Staph and S. Pneumo

Covers the same as the others but also ACBEB and CAP

Question 12

Whats the BBW on FQs?

Who is the risk further increased in?
3

Answer 12

associated with an increased risk of tendinitis and tendon rupture in all ages

60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants

Question 13

What kind bacteria does Metronidazole (Flagyl) cover?2

What is it the treatment of choice for?4

Answer 13

Anaerobes (gram + and -) and Protozoa

Anerobic infections

Bacterial vaginosis

Trichomoniasis

C. difficile diarrhea

Question 14

What trimester is Metronidazole (Flagyl) approved for?

What are its major interactions we have to watch out for?

Answer 14

1st trimester

ETOH