Inherited Cardiac Conditions Flashcards
what are the 4 types of cardiomyopathy
Hypertrophic
Dilated/Idiopathic
Arrhthmogenic Right Ventricular
Restrictive
what are signs of HCM
forceful and jerky pulse
4th heart sound
Mid systolic murmur
what are the signs of RCM
rapid x and y descent of JVP
3rd and 4th heart sound
hepatomegaly
ascites
what are the signs of HCM on ECG
LVH
Progressive T wave inversion
deep Q waves
how is RCM diagnosed
Cardiac catherterization
what are the pathological effects of cardiomyopathy
LVOT obstruction
Reduced ejection fraction
Mitral regurgitation
Rhythm disturbances
what are the histological features of dilated cardiomyopathy
- myocardial cell hypertrophy increased length without increased diameter
- increased interstitial fibrosis.
what are signs of dilated cardiomyopathy
Increased systolic and diastolic volume with low Ejection Fraction
S3
Gallop rhythm
what happens in ARVC
Heart muscle is replaced by fibrous and fatty tissue - RV
what are signs of ARVC
- ventricular arrhythmias of RV origin,
- sudden death
what are ECG characteristics of ARVC
- T-wave inversion beyond lead V1
- QRS duration in V1 > or = 110 msec
- a longer QRS duration in the right then left precordial leads.
what is RCM
walls of the ventricles become stiff, but not necessarily thickened abnormal filling with blood
what are physiological effects of RCM
Reduced EDV, normal ESV, increased Left ventricular filling pressure, normal EF
where is mutations seen in HCM
- sarcomeric genes
- mitochondrial DNA
where are mutations seen in ARVC
cardiac ryanodine receptor