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Mar: prep for clinicals > Inhaled Anesthetics, NMBD > Flashcards

Inhaled Anesthetics, NMBD Flashcards

1
Q

Halothane
Blood:Gas Partition Coefficient
MAC
Vapor Pressure

A

B:G = 2.54
MAC = 0.75%
Vapor Pressure = 243 torr

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2
Q

Enflurane
Blood:Gas Partition Coefficient
MAC
Vapor Pressure

A

B:G = 1.90
MAC = 1.63%
Vapor Pressure = 175 torr

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3
Q

Isoflurane
Blood:Gas Partition Coefficient
MAC
Vapor Pressure

A

B:G = 1.46
MAC = 1.17%
Vapor Pressure = 238 torr

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4
Q

What is MAC awake, MAC asleep, and MAC Bar of Isoflurane on a 35yo pt?

A

MAC Awake (0.3-0.5%): 0.351-0.585
MAC asleep (1.3%): 1.521
MAC bar (1.7-2%): 1.989-2.34

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5
Q

Nitrous Oxide
Blood:Gas Partition Coefficient
MAC

A

B:G = 0.46
MAC = 104%

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6
Q

Desflurane
Blood:Gas Partition Coefficient
MAC
Vapor Pressure

A

B:G = 0.42
MAC = 6.6%
Vapor Pressure = 669 torr

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7
Q

What is MAC awake, MAC asleep, and MAC Bar of Desflueane on a 35yo pt?

A

MAC awake (0.3-0.5%): 1.98-3.3
MAC Asleep (1.3%): 8.58
MAC bar (1.7-2%): 11.22 - 13.2

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8
Q

Sevoflurane
Blood:Gas Partition Coefficient
MAC
Vapor Pressure

A

B:G = 0.69
MAC = 1.8%
Vapor Pressure = 157 torr

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9
Q

What is MAC awake, MAC asleep, and MAC Bar of Sevoflurane on a 35yo pt?

A

MAC awake (0.3-0.5%): 0.54 - 0.9
MAC asleep (1.3%): 2.34
MAC bar (1.7-2%): 3.06 - 3.6

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10
Q

1 Hz/second decreasing to 0.1 Hz q 10 seconds

A

Single Twitch

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11
Q

3 short bursts followed by 3 short bursts
Uses 50 Hz

A

Double Burst

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12
Q

4 stimuli at 2 Hz in ½ second

A

Train of Four

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13
Q

Very rapid, 50 Hz for 5 seconds – Continuous

A

Tetanic Stimulation

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14
Q

Single twitch 3 seconds after tetanic stimulation

A

Post-Tetanic Stimulation

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15
Q

Succinylcholine:
Dose
Onset
Duration

A

1 - 1.5 mg /kg IV
Onset - 30 to 60 seconds
Duration - 3 to 5 minutes

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16
Q

Lower Dibucaine # indicates what?

A

Prolonged Succinylcholine effects - No butyrylcholinesterase

17
Q

High Dibucaine # indicates what?

A

Normal response to Succinylcholine

18
Q

Dantrolene
Use
Dose
Max dose

A

Malignant Hyperthermia
2 mg/kg IV
Max dose 10 mg/kg IV

19
Q

MACawake

A

0.3-0.5 MAC

20
Q

MAC-BAR

A

1.7-2.0 MAC

21
Q

For each decade above 50 years old, MAC decreases by..

A

6%

22
Q

Pancuronium (Pavulon)
Intubating Dose:
Onset:
Duration:
Short or long-acting?

A

Intubating Dose: 0.1 mg/kg
Onset: 3-5 mins
Duration: 60-90 mins
Most common long-acting NMBD

23
Q

What are the four intermediate-acting NMBDs?

A

Vecuronium
Rocuronium
Cisatracurium
Atracurium

24
Q

Vecuronium (Norcuron)
Intubating Dose:
Onset:
Duration:

A

Intubating Dose: 0.1 mg/kg
Onset: 3-5 mins
Duration: 20-35 mins

25
Q

Rocuronium (Zemuron)
Intubating Dose:
Onset:
Duration:

A

Intubating Dose: 0.6 mg/kg or 1.2 mg/kg
Onset: 3-5 mins; 1-2 mins with a larger dose
Duration: 20-35 mins

26
Q

Cisatracurium (Nimbex)
Intubating Dose:
Onset:
Duration:

A

Intubating Dose: 0.1 mg/kg
Onset: 3-5 mins
Duration: 20-35 mins

27
Q

Mivacurium (Mivacron)
Intubating Dose:
Onset:
Duration:

A

Intubating Dose: 0.15 mg/kg
Onset: 2-3 mins
Duration: 12-20 mins

Not used much anymore - “move-a-curium”

28
Q

What muscle are the best indicators of diaphragmatic and laryngeal neuromuscular blockade?

A

Orbicularis Oculi & Corrugator Supercilli (Facial nerve)

29
Q

What muscle is most resistant to neuromuscular blockade?

A

Diaphragm

30
Q

What muscle is the gold standard for determination of NMB recovery?

A

Adductor Pollicis (ulnar nerve)

31
Q

What four factors determine how much a muscle is subject to neuromuscular blockade?

A
  • # of presynaptic ACh vesicles
  • # of postsynaptic ACh receptors
  • Blood flow to muscle
  • NMB potency
32
Q

Faster onset of neuromuscular blockade to a muscle means that that muscle experiences a ____ recovery.

A

Slower

Mar: prep for clinicals (19 decks)

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