Hypotension & Hypertension Rescue Meds

Question 1

What is the dose of phenylephrine for hypotension?
is it alpha or beta?

Answer 1

50 - 100 mcg
Alpha only

Question 2

What dose of labetalol is used for hypertension?

Answer 2

2.5 - 5 mg (Can increase to 10mg)

Question 3

What dose of Propanolol is given for B1 and B2 blocking?

Answer 3

1 - 10 mg

Question 4

What dose of esmolol is utilized for hypertension (or tachycardia)?

Answer 4

10 - 80 mg

Question 5

What dose of hydralazine is utilized for hypertension?

Answer 5

Initial dose: 2.5 mg - 10 mg

Question 6

What is the dose of ephedrine for hypotension?
Is ephedrine α or β?

Answer 6

• 5 - 10mg
• Ephedrine is both α & β

Question 7

What dose/infusion rate would you use for Epi?

Answer 7

Infusions:
- 1-2 mcg/min (B2)
- 4 mcg/min (B1)
- 10-20 mcg/min (alpha mostly)

Bolus:
- 1-2mcg

Question 8

What bolus dose would you use for vasopressin? what does it do in the body for HoTN?

Answer 8

1 - 2 units
increases CO and increases PVR

Question 9

MOA of Nitric Oxide

Answer 9

Inhibits Ca++ entry into the smooth muscle and increases uptake by the ER

Question 10

Sodium Notroprusside MOA and dose

Answer 10

Dissociates upon contact with oxyhemoglobin and releases NO and cyanide
Dose: 0.3 mcg/kg/min (2mcg/kg/min max)

Question 11

Nitroglycerin MOA and dose

Answer 11

Converts into NO in the body
Dose: 5 - 10 mcg/min infusion (titrate to effect)

good to use with sphincter of Oddi spasm

Question 12

Nicardipine MOA and dose

Answer 12

Bind to voltage-gate Ca channels and decrease Ca influx
Dose: 5mg/hr increase by 2.5mg/hr x4 to a max a 15mg/hr