Inhalational Anaesthetics Flashcards

1
Q

How are inhaled anaesthetics transported?

A

in carrier gasses

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2
Q

Name 3 types of inhaled anaesthetics

A
  • Halothane
  • Isoflurane (MUST KNOW)
  • Sevoflurane (MUST KNOW)
  • Desflurane
  • Enflurane
  • Methoxyflurane
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3
Q

What are these inhaled anaesthestics known as

A

Volatile anaesthetic agents

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4
Q

How is the level of agent determined

A

by dial up vaporiser

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5
Q

What do all inhaled anaesthetics cause some degree of

A
  • respiratory depression

- cardiovascular depression

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6
Q

Do inhaled anaesthetics provide analgesia?

A

no

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7
Q

What are the two most commonly used inhaled anaesthetics

A

Isoflurane and Sevoflurane

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8
Q

Name the two carrier gasses?

A

Oxygen, Nitrous oxide, Carbon dioxide

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9
Q

What cylinder is oxygen kept in?

A

Black cylinders with white shoulders

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10
Q

What are 3 uses of oxygen

A
  • 100% given to animals with anaemia, pulmonary pathology, hypoventilation, animals recovering from N2O anaesthesia/ supplied during recovery if needed
  • Used operatively routinely
  • Used pre-operatively if you think intubation will be difficult e.g. brachycephalics
  • Post operatively
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11
Q

Name a benefit of oxygen?

A
  • Does not depress ventilation
  • Does not cause toxic nervous changes
  • Does not cause toxic pulmonary changes
  • Can be combined with nitrous oxide
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12
Q

How is nitrous oxide delivered?

A

from compressed air tanks

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13
Q

What is nitrous oxide combined with

A

oxygen

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14
Q

What % of concentration will provide analgesic effects?

A

20%

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15
Q

What % is nitrous oxide usually delivered at?

A

66% (33% oxygen)

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16
Q

What is the ratio of nitrous oxide to oxygen in non-rebreathing circuits?

A

2:1

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17
Q

What is the ratio of nitrous oxide to oxygen in rebreathing circuits?

A

1:1

18
Q

Why can the use of nitrous oxide cause the anaesthetic sparing effect

A

if delivered at 66% then lowers need for high volatile agent levels

19
Q

With what inhaled anaesthetic does nitrous oxide have a second gas effect?

A

Halothane

20
Q

What cylinders do N2O come in?

A

Blue

21
Q

What must you do once N20 is switched off?

A

oxygenate patient

22
Q

Name 3 negatives with nitrous oxide?

A
  • not to use more than 80% (will lower oxygen below normal levels and patient will go hypoxic)
  • Hypoxia
  • N20 diffuses into gas-filled spaces and accumulates
  • Do not use in bowel obstruction
  • Do not use in middle ear disease
  • Delivering nitrous oxide with pneumothorax can double the size of the pneumothorax in 10 minutes
23
Q

When might hypoxia occur? And how do you avoid it

A

if animal is breathing room air - as room air contains high levels of nitrogen
Avoid it by giving al patients 5-10 minutes of pure oxygen once N2O is switched off

24
Q

What piece of equipment should you use if concerned about hypoxia?

A

Pulse oximeter

25
Q

What cylinder is carbon dioxide in?

A

grey

26
Q

When is co2 used?

A

if patient is hypo-capnic

27
Q

At what level is co2 used?

A

4%

28
Q

Name 3 advantages of inhalational anaesthetics over injectable anaesthetics?

A
  • depth of anaesthesia readily altered
  • Concentration of anaesthetic in blood or brain may be altered rapidly by changing vaporiser setting
  • Elimination of inhaled agents occurs mainly via the lungs therefore advantage of liver/kidney patient
  • Allows constant delivery of oxygen alongside agent
  • Most patients are intubated therefore IPPV may be performed and anaesthetic is ‘safe’
  • Delivered to the lungs and then goes very quickly across the blood brain barrier to the brain and into the CNS
29
Q

Name 3 disadvantages of using inhaled anaesthesia over injectable anaesthesia?

A
  • need for anaesthetic machine and range of equipment (costly)
  • Hazards, personnel risk, explosion risk
  • Knowledge required of circuits and machine
  • Induction and recover possibly delyaed due to lung pathology (not great induction agents)
  • Only alternative is IV total anaesthesia
30
Q

What is MAC

A

minimum alveolar concentration = measure of the anaesthetic potency

31
Q

How is MAC measured

A

it is the quantity of anaesthetic required to immobilize 50% of patients

32
Q

Are MAC’s with a lower or higher number more potent?

A

lower MAC numbers are stronger and more potent

33
Q

What is blood gas solubility?

A

how soluble the gas is into the blood which then gets soaked up by blood and forms a reservoir in plasma - making it more difficult to pass through alveoli and pass the blood brain barrier

34
Q

Are more soluble or less blood gas soluble agents better? And why?

A

Low, they tend to have a more rapid induction and recovery

35
Q

Name an inhalational anaesthetic with low blood gas solubility

A

Sevoflurane

36
Q

Name an inhalation anaesthetic with high blood gas solubility

A

Halothane

37
Q

Which is more soluble: isoflurane or sevoflurane?

A

Isoflurane

38
Q

Which popular inhalational anaesthetic has a pungent smell?

A

Isoflurane

39
Q

Name 3 benefits of Isoflurane?

A
  • relatively fast induction and recovery in comparison to Halothane
  • Good muscle relaxation
  • Fast recovery
  • Does not sensitise the heart to arrhythmias
  • Dose dependent
  • Licensed for variety of species
  • Greater safety margin than Halothane
40
Q

Name 3 negatives with Isoflurane?

A
  • Not as fast induction or recovery as Sevoflurane
  • Transient excitability especially following painful surgery
  • Hypotension can occur due to CVS depression
  • Potent respiratory depressant
  • Poorly tolerated for mask induction due to smell
  • Not good analgesic on its own
41
Q

Name 4 characteristics of Sevoflurane

A
  • Rapid induction and recovery in comparison to Isoflurane
  • Lower blood gas solubility than Iso
  • Odourless / pleasant non-irritant odour
  • Unstable in presence soda lime
  • More expensive than Iso
  • Can be used for mask induction
  • Non-irritant to airways
  • Can be used on exotics
42
Q

What happens when Sevoflurane is in the presence of soda lime

A
  • Unstable
  • Degrades producing toxic metabolites (compound A which is proven to produce renal pathology in rats though not reported in small animals)