Inhalation Anesthetics Flashcards
Carrier gas for inhalants
Oxygen
Concentration of anesthesia in the body is changed by adjusting the
vaporizer
Inhalants are eliminated by the
lungs
Inhalants provide analgesic effects by creating
unconsciousness
This is needed in order to convert the liquid to a gas
Vaporizer
To induce an animal, dials are set
higher concentrations
For maintenance, dials should be adjusted to
lower concentrations
For recovery, dials are _______ ___ in order to reverse anesthetic effects
turned off
Oxygen is color coated in
green tanks
Oxygen tanks are attached to the machine by the
yoke
A full E oxygen tank will last approximately
11 hrs
A full H oxygen tank will last approximately
110 hrs
An full E tank of oxygen contains
700 L
A full H tank of oxygen contains
7000 L
When the pressure in falls below ____ psi, change the tank
500
For many years, this was the most widely used anesthetic because of several desirable effects
Minimal <3 and respiratory effects
Good muscle relaxation
Diethyl Ether
This is a tracheal irritant that causes prolonged induction and recovery
Post op nausea and V+
Flammable and explosive
Diethyl Ether
Most commonly used Halogenated compounds
Isoflurane and sevoflurane
Halogenated agents are ________ at room temperature
liquid
The rate of diffusion of inhalants depends on 2 things
- Lipid solubility
2. Concentration gradient
Mixed with O2, the anesthetic gas diffuses across the
alveolar membranes
3 methods of inhalant delivery
- Mask
- Induction chamber
- Intubation
This method of delivery is easy if animal is docile and calm
(-) Can’t do if airway problems exist, can’t effectively ventilate the pt, and causes more waste gas
Mask induction
This method of delivery is when you don’t have to be near the animal to deliver the inhalant
(-) Cant monitor well, excessive waste gas, and size limitation of pt
Induction Chamber
This method of delivery gives you an airway to ventilate and greater depth control, protects against aspiration, and produces less waste gas
(-) Requires skill
Intubation
Inhalants are carried to the tissues by way of the
blood
Because of high ______ solubility, the agents readily leave the blood and enter the brain
lipid
Anesthesia is maintained as long as the concentration in the _____ is adequate
brain
Isoflurane, sevoflurane, and desflurane undergo minimal ______ metabolism
liver
If an agent has high lipid solubility, it will accumulate in
body fat
It is not acceptable to _____ inhalants in the same vaporizer
combine
It is okay to ___ from one inhalant to another
switch
This measures the tendency of a liquid anesthetic to evaporate
Vapor Pressure
Increased VP =
The faster it evaporates
Allow for precise delivery of anesthetic agent
Precision vaporizer
An inhalant is considered volatile if it
evaporates easily
A ratio of the concentration of an inhalant in the blood and the alveoli
Solubility Coefficient
OR Partition coefficient
An agent with low solubility
enters and leaves the blood quickly
An agent with high solubility
stays in the blood, and doesn’t leave quickly
Rapid induction and recovery along with rapid response to changes in concentration during maintenance
Low partition/solubility coefficient
Slow induction and recovery, with slower responses to concentration changes during maintenance
High partition/solubility coefficient
MAC
Minimum Alveolar Concentration
The lowest concentration at which 50% of patients show no response to a painful stimulus
MAC
The lower the MAC, the
more potent the inhalant is
The higher the MAC the
weaker the inhalant
If an inhalant is more potent, we need
less
If an inhalant has a low MAC, then you will need ____ dial settings
lower
The ideal agent’s VP, SC, AND MAC
VP: Lower
SC: Lower
MAC: Lower
Stored in purple containers
Isoflurane
High VP, extremely low SC, and Moderately low MAC (1.3%-1.63%)
Approved for use in dogs and horses, but used in a variety of species
Pungent odor, so it’s difficult to mask pts
Little to no analgesic effect
Isoflurane
Isoflurane is the choice inhalant for
cardiac pts
Isoflurane’s liver metabolism %age
0.2%
Stored in yellow containers
Sevoflurane
Second most commonly used inhalant
Labeled for use in dogs, but used in other species
Non-irritating and has a more pleasant odor
Sevoflurane
10x more expensive than Isoflurane
Sevoflurane
High VP, Extremely low SC, and MAC is 2.34-2.58%
Sevoflurane
This inhalant causes renal damage in rats
sevoflurane
Biotransformation of sevoflurane
2.5%
Sevoflurane has a ______ SC than Isoflurane
lower
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Due to expense and some adverse effects, it is not commonly used in veterinary medicine
“One breath” anesthesia
Very pungent odor, causes C+ and breath-holding
Desflurane
Desflurane has an extremely high VP so it requires a special
vaporizer
Extremely high VP, Very high MAC, Lowest SC
Desflurane
Biotransformation of Desflurane
0.02%
Recently became unavailable in the US and was replaced with Isoflurane and Sevoflurane
Myocardial depressant
Associated with malignant hyperthermia
Halothane
Hyperthermia is most common in
swine
High VP, Moderately Low SC, and VERY low MAC
Halothane
Biotransformation of Halothane
20-46%
Halothane is most likely to cause ___________ in dogs
<3 arrhythmias
No longer commercially available in North America
Requires a non-precision vaporizer
High lipid solubility, retained into fat stores
Methoxyflurane
Low VP, considerably high SC, and low MAC
Methoxyflurane
Used in human medicine, has not found acceptance in veterinary medicine
Rapid induction and recovery
Profound resp. depression
Causes muscle hyperactivity in dogs
Enflurane
Stored in blue containers
Nitrous Oxide
Still used in human medicine, but lesser in veterinary medicine
“Laughing gas”
Second-gas effect to speed induction with other inhalants
NOT an anesthetic, it’s an analgesic
Nitrous Oxide
Nitrous Oxide is a _____ at room temp
gas
MAC level of Nitrous Oxide
200-250%
Nitrous Oxide should not be used in what type of pts?
intestinal obstruction, GDV, pneumothorax, and equine patients
Patients should be kept on high ______ flow rates for 5 minutes after discontinuation of N2O to replace it in the blood and alveoli
O2
Full tank pressure of N2O
745 psi
Prevents the flow of nitrous oxide if the oxygen flow stops for any reason
Automatic failsafe
This can result from low SC by waking up too fast
Give premeds to prevent
Emergence delirium
Relates to induction and recovery rates
SC
Relates to precision and delivery method
VP
Relates to potency
MAC