Anesthetic Agents and Adjuncts: Preanesthetics Flashcards
Not a true anesthetic but used for other desirable effects such as sedation, tranquilization, analgesia, and anticholinergics
Anesthetic adjunct
Bind to and stimulates receptors
Pure agonist
Bind to receptors but do not stimulate them (reversal agents)
Blockers
Pure antagonists
Bind to and partially stimulate receptors
Partial agonists
Bind to more than one receptor type and simultaneously stimulate at least one, and block at least one
Agonists/Antagonists
These must be administered as adjuncts
analgesics
These type of drugs can’t be administered in the same syringe
Incompatible drugs
Drugs that are safely mixed together in the same syringe
Combination drugs
Often combined with ketamine in a 50:50 mixture
Valium (diazepam)
A term that describes the period immediately preceding the induction of anesthesia
Preanesthesia
The process by which an animal leaves the normal conscious state and enters an unconscious state
Induction
“Heart protectants”
Anticholinergics
Cause calming and sleep effects
Tranquilizers and Sedatives
AKA narcotics
Cause analgesic effects
Opioids
When should preanesthesia drugs be given?
15-20 minutes prior to induction
Controversial as pre-meds but help combat adverse side effects
Anticholinergics
AKA parasympatholytics
Block the binding of acetylcholine to prevent bradycardia, salivation, peristalsis, and pupil constriction
Works on the vagus nerve
Can be reversed with physotimine or pilocarpine
Causes bronchodilation
Anticholinergics
2 anticholinergics used in preanesthesia
Atropine and glycopyrrolate
An older drug derived from the nightshade plant
Short duration of action, but fast onset (used for emergencies)
Treats organophosphate toxicity
Increases the firing of the SA node
Can cross the placental barrier, but carrier of other substances
Atropine
A newer synthetic drug approved for dogs and cats
Slow onset, long duration
Minimally crosses the placental barrier
Less tendency to cause tachycardia
Glycopyrrolate
These drugs can cause ataxia, prolapse of the third eyelid, respiratory distress, and unusual behaviors
Tranquilizers and Sedatives
3 classes of sedatives/tranquilizers
- Phenothiazines
- Benzodiazepines
- Alpha 2 agonists
These sedatives are NON CONTROLLED substances that suppress the sympathetic nervous system
May cause hypothermia
SHOULD NOT BE GIVEN TO SEIZURE PTS
EX: Acepromazine
Phenothiazines
Bright yellow in color
Shouldn’t be used in stallions, epileptics, boxers, liver failure pts, and hypotensive pts
Acepromazine
These are minor tranquilizers with a wide safety margin, mostly used as muscle relaxers (not reliable sedatives)
Cardiovascularly friendly drugs
Benzodiazepines
Drug used to reverse benzodiazepines
flumazenil
4 benzodiazepines
- diazepam
- zolazepam
- midazolam
- lorazepam
Diazepam is AKA
valium
only licensed benzodiazepine licensed for animals
zolazepam
This drug is the drug of choice for seizure and cardiovascular pts, is cardiovascularly friendly, compatible with ketamine
Controlled and given IV
Diazepam
This drug is used as an appetite stimulant in ruminants and cats
Can be given in multiple routes
Midazolam
These drugs are highly reversible and should be given in young, healthy pts ONLY
Act as sedatives/tranquilizers and has slight analgesic effects
Alpha 2 agonists
First widely used alpha 2 agonist
Can be combined with other pain meds as a better sedative/analgesic
Can be reversed with Yohimbine
Xylazine
Xylazine is AKA
Rompun, Anased
Dosing is based on body surface area
Most commonly used A2A in dogs and cats
Mostly used in horses
Reversed with atipamazole
Dexmedetomidine
Dexmedetomidine is AKA
metetomedine
Analgesic used in horses for colic pain
Detomidine
Romfidine is AKA
Sedivet
4 A2A’s
- Xylazine
- Dexmedetomidine
- Detomidine
- Romfidine
3 Reversal agents
- . Tolazoline
- Yohimbine
- Atipamazole
Reversal agents are AKA
Alpha 2 Antagonists
Used to reverse Xylazine in ruminants
tolazoline
Used to reverse xylazine (rompun) in dogs, cats, horses and exotics
Yohimbine
Used to reverse dexmedetomidine
atipamazole
Atipamazole is AKA
Antisedan
Derivatives of opium
Excellent analgesic effects
Opiates
4 opioid receptors
- mu
- kappa
- sigma
- delta
Narcotics’ duration of action is dependent on the
route
Pure agonists =
excellent pain relief, more side effects
Partial agonists =
good pain relief, few side effects
Agonist/antagonist =
mild pain relief, very few side effects
Narcotics that stimulate all receptors
Given to pts with severe burns, amputations, deglovings, horrible orthopedic injuries
Ex: morphine, hydromorphone, oxymorphone, fentanyl, meperidine
Pure agonists
First narcotic used
Use with caution in horses and cats
Morphine
Similar to morphine in effects
Safer to use in cats
Not as potent as oxymorphone, but less expensive
hyrdromorphone
Weak analgesia
AKA pethidine
Meperidine
Greater potency than morphine with fewer side effects and longer duration
Great for sick or cardiovascular impaired pts
Expensive
Oxymorphone
One of the most potent analgesias
Most common route is transdermal patch
Fentanyl
Only partially stimulate the opioid receptors
Ex: buprenorphine
Partial agonist
Given PO to cats
Longest duration of any analgesia (6-12 hrs)
Come in ampules
Used for pts with spay, cryptorchid castration, or lacerations
Buprenorphine
These provide pain relief but do not depress the respiratory and cardio systems as much as narcotics
Don’t stimulate the mu receptors, but instead stimulate kappa receptors
Ex: Butorphanol and Nalbuphine
Agonist-antagonist
Most effective on mild to moderate visceral pain
Does not depress respiration at higher doses (ceiling effect)
Low doses = antitussive
Butorphanol
Butorphanol is AKA
Torbugesic/Torbutrol
Only injectable opiod that is not a controlled substance in the US
Weak analgesia/sedative
Strong antagonist properties
Nalbuphine
Nalbuphine is AKA
Nubian
These type of drugs bind to receptors without stimulating them
No clinical effect on their own
Reverse pure agonists, partial agonists, and agonist/antagonists
AKA Reversal agents
Ex: Naloxone
Pure Antagonists
Blocking agents for opioids (reversal agents)
Narcotic antagonists
Effective in reversing narcotics in emergency situations
Naloxone
Naloxone is AKA
Narcan
A hyponotic state produced in which the patient appears sedate, yet can be aroused with stimulation
Narcosis
Display odd behavior patterns on opioids
Cats
Most effective for severe pain
Pure agonist
Derived from the nightshade plant and acts to prevent bradycardia
Avoid in horses due to potential colic
Atropine
Anticholinergic with long duration, better for sick patients
Avoid in horses due to potential colic
Glycopyrrolate
A phenothiazine that should be avoided in epilleptics and stallions
Supresses the sympathetic nervous system to help with nausea and cause vasodilation
Good in geriatric pts
Acepromazine
A benzodiazepine used often in heart pts
Stimulates appetites in felines
Muscle relaxer and good for cardio pts
AKA valium
diazepam
A component of telazol
Zolazepam
Analgesic and sedative
AKA Rompun
Xylazine
A2A approved for use in horses but can be used in other species
VERY POTENT
Detomidine
Most potent sedative
Detomidine
3 pure agonists
Morphine, hydromorphone, oxymorphone
Dexmedetomidine antagonist
Antisedan
Can be given PO in cats
Longest duration of action for narcotics
Buprenorphine
AKA Torbugesic
Butorphanol
VERY WEAK NARCOTIC
Nalbuphine
Xylazine antagonist
Yohimbine
Reverses all narcotics
Naloxone
Transdermal narcotic
Fentanyl
These type of drugs prevent bradycardia and decrease salivation
Not controlled
Reversed with physostigmine or pilocarpine
Anticholinergics
These type of drugs are used for sedation and hypotension
Not controlled and not reversible
Phenothiazines
These type of drugs are used for muscle relaxation
CONTROLLED
Reversed with flumazenil
Benzodiazepines
These type of drugs are used for sedation with analgesia
Not controlled
Reversed with yohimbine or atipamazole
Alpha 2 Agonists
These type of drugs are used to reverse Alpha 2 Agonists to wake patients
Not controlled
Alpha 2 Antagonists
These type of drugs are used for pain relief
Some are controlled and reversible
Narcotics
These type of drugs reverse the effects of narcotics to make the patient more alert
Not controlled
Narcotic Antagonists