influenza virus epidemiology and pathogenesis lectures 3 and 4 Flashcards
what is critical determinant of host range
the specificty of receptor binding
what protects humans from many avian flu viruses
the fact we have mostly 2-6 linkage.
which HA proteins have a high affinity for 2-3 linkage in avian cells and 2-6 in humans
H1, H2, H3
which strains tend to be low pathogenecity
H1, 2, 3
what are H5 and 7 known as
highly pathogenic avian flu viruses
in humans is H5 and 7 restricted to the respiratory tract
no
what is the typical outcome of flu virus infection
tracheobronchitis
what are the primary sites of infection
epithelial cells lining the respiratory tract
name some complications of this disease
viral pneumonia, cardiac involvment, CNS invovlvement
why is virus transmission better in low humidity
droplets are smaller in air for longer and increased chnace of inhalation.
why is transmission better in low temps
more virus is released and more stable
why was H1N1 1918 more lethal
cleavability of HA protein
what is the incorporation of single nucleotide changes called
antigenic drift
where are most drfit changes
on HA1
when does antigenic shift happen
when segments from differetns flus infect smae cell
