HPV: pathogenesis Flashcards
what does transfection of HPV16 and 18 do
when transfected into primary keratinocyte it leads to immortalisation and transformation
what is the major function of E6 and 7t
they maintain undifferentiated and differentiated cells in the suprabasal region
how does E7 function
binds to cellular factors
name some the cellular factors that E7 binds to and how
retinoblastoma family tumour suppressor proteins binds to them by highly conserved LXCXE motif
what does the Rb family control
G1-S phase it regulates E2F family transcription factors
what happens when E7 targets pRb successfully
increases p53 levels
what is the best studied interaction of E6
interacts with host E3 ubiquitin ligases
how does E6 degrade p53
needs Ub ligase E6-AP
what does high risk HPV E6 bind to
PDZ domains E6 ahs a PDZ binding motif at extreme C-terminus
what is the structure of the E5 and where is it found
cytoplasmic localisation
novel ion channel of viroporin
what is the function of E5
EGFR expression and signalling in differentiated cells
