Influenza Flashcards
What symptoms does influenza cause?
Respiratory and non reparatory: Headache Cough and sore throat Vomiting Aches in joints
What are the surface proteins on influenza?
Haemagglutin
Neuramindase
Matrix protein 2
What are features of haemagglutin?
Basic sialic acid receptors
Agglutinates RBC
Antigenic
What are features of neauramindase?
Cleaves sialic acid to release virus
Degrades murin
Antigenic
What are features of matrix protein 2?
Forms proton chanel that facilitates uncoating and assembly?
Describe the outer layer of influenza.
Lipid bilayer
Supported by M1 protein
Describe the necleocapsid.
8 different single stranded RNA, nucleoprotein and RNA polymerase (2 types)
Who serotype of influenza accounts for most epidemics of influenza?
Influenza A
Define epidemic
Rapid spread of infection in a city over a short period of time
Define pandemic
An epidemic that spreads across boarders effecting large numbers
What are used to subtype influenza?
Two surface glycoprotein
What influenza viruses do we vaccinate against?
A and B
What are the stages of influenza replication?
Attachment Uncoating Transcription Replication Assembly Budding
What are the two important sites on haemagglutinin?
Receptor binding site
Cleavage site
What are the two mechanisms which keep changing the structure of influenza?
Antigenic drift (minor changes in antigenic sites of HA and NA) Antigenic shift (major changes due to a re assortment of genes that occur when two different influenza viruses infect same host)
