Adaptive Immune System Flashcards
What are features of the adaptive immune system?
Specific to certain antigens
Gained after exposure
Delay before effective
Memory
What is adaptive system carried out in?
Lymphatic system
Who can carry out adaptive immune systems?
Vertebrates
What cells are in the adaptive immune system?
Lymphocytes
Cytotoxic T cells
T helper cells
B cells
Where do lymphocytes originate?
Bone marrow
Where do T cells mature?
Thymus
Where do B cells mature?
Bone marrow
What are the secondary lymphoid organs?
Lymph nodes
Spleen
What do lymph nodes filter?
Lymph
What does the spleen filter?
Blood
What are examples of APC?
Dendritic cells
B cells
Macrophages
What’s the humoral defence?
Defend against pathogens and toxins in extracellular fluid
What cells are involved in humoral defence?
B cells
What’s the role of cell mediated response?
Defence against infected cells, cancer cells and transplants
Who carries out cell mediated response?
T cells
What’s an epitope?
Antigenic determinant
Where are B and T cell receptors?
In their plasma membranes
How many antigen epitope is a B or T cell specific for?
1
Which cells are removed when B cells undergo selection process when developing?
Self reactive cells
What are the types of antibodies produced?
IgM IgD IgE IgA IgG
Which Ig is the first to be further after antigen exposure?
IgM
What two processes do T cells go under?
Positive selection
Negative selection
What T cells get selected?
Cells that’s don’t recognise self MHC
Cells that recognise self MHC too strongly
How do T cells get activated?
By recognition of antigen presented on MHC molecules
