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Practice > Infliximab-Norepinephrine > Flashcards

Infliximab-Norepinephrine Flashcards

1
Q

What is the brand name of Infliximab?

A

Remicade

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2
Q

What is the class of Infliximab?

A

TNF alpha inhibitor

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3
Q

Caution with use of Infliximab…

A

In combo with other drugs that affect the immune system

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4
Q

Do not give Infliximab to patients with…

A

an active infection (evaluate for TB and get up to date on vaccines)

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5
Q

AE of Infliximab

A

Infusion-related reactions (similar to the flu) –> more infusions increases tolerance, but may require pretreatment

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6
Q

Very rare AE of Infliximab

A

Hepatosplenic T-cell lymphoma

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7
Q

What is the brand name of Iron Dextran Complex?

A

INFeD, Dexferrum

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8
Q

What is the class of Iron Dextran Complex?

A

Parenteral iron product

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9
Q

AE of Iron Dextran Complex

A

Infusion related reactions (flushing, N/V, diaphoresis, hypotension) - 10% chance

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10
Q

Requires a test dose with 1st use…

A

Iron Dextran Complex (INFeD)

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11
Q

Z-track method with IM use

A

Iron Dextran Complex (INFeD)

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12
Q

What is the brand name of Iron Sucrose?

A

Venofer

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13
Q

What is the class of Iron Sucrose?

A

Parenteral iron salt

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14
Q

AE of Iron Sucrose

A

Same infusion-related reactions as iron dextran, but not as severe

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15
Q

Is a test dose needed with Iron Sucrose?

A

NO

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16
Q

Is a test dose needed with Iron Dextran?

A

YES

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17
Q

What is the brand name of Isoproterenol?

A

Isuprel

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18
Q

What is the class of Isoproterenol?

A

Beta 1,2 agonist

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19
Q

Indication of Isoproterenol?

A

Bradyarrhythmias until a pacemaker can be inserted (also used for Torsade De Pointes) –> Short-term drug, not really used for anything else

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20
Q

AEs of Isoproterenol

A

Arrhythmias, PVCs, CNS effects, hyperglycemia, hypokalemia, N&V

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21
Q

What is the brand name of Ketamine?

A

Ketalar

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22
Q

Indication of Ketamine

A

General anesthetic used when cardiodepression must be avoided, also used for sedation and analgesia

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23
Q

Also known as Special-K

A

Ketamine

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24
Q

Ketamine CI with

A

Increased ICP, HTN, aneurysms, CHF, angina, psychotic disorders (anything that causes BP to go up)

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25
Q

Population Ketamine is preferred in

A

Children, but out-of-body experiences can occur

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26
Q

AEs of Ketamine

A

“Emergent Reactions”- vivid dreams, hallucinations, and delirium can occur up to 24 hours after dose (pre-treatment with benzos), lowers seizure threshold and stimulates salivary secretions

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27
Q

Caution with use of Ketamine

A

Pre-op or patients with cardiac issues

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28
Q

What is the brand name of Ketorolac?

A

Toradol

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29
Q

What is the class of Ketorolac?

A

Super-potent parenteral NSAID

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30
Q

30 mg Ketorolac = ___ mg morphine

A

12

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31
Q

Ketorolac CI with…

A

Active peptic ulcer disease, recent GI bleed, ADVANCED RENAL DISEASE or risk of renal failure, surgery, CVA, s/p CABG

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32
Q

Indication of Ketorolac?

A

Short-term pain management (<5 days only- IV/IM/PO combined)

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33
Q

Dose adjustments of Ketorolac?

A

Reduced if 65 yo, no more than 60 mg/day in moderate renal impairment

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34
Q

Do not use Ketorolac in…

A

advanced renal impairment

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35
Q

What is the brand name of Labetolol?

A

Normodyne, Trandate

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36
Q

What is the class of Labetolol?

A

Non-selective beta blocker and alpha 1 blocker

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37
Q

Indication of Labetolol?

A

BP control

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38
Q

What is the brand name of Leucovorin?

A

Wellcovorin

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39
Q

Indication of Leucovorin?

A

Folic acid derivative used to “rescue” patients from high-dose methotrexate therapy, also used to enhance the effect of 5-FU

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40
Q

Critical drug to have on hand

A

Leucovorin

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41
Q

Drugs that Leucovorin must be given with in combo

A

High-dose MTX, chemotherapy

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42
Q

If you aren’t clearing MTX fast enough, the hospital will give you more…

A

Leucovorin

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43
Q

What is the brand name of Levetriacetam?

A

Keppra

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44
Q

What is the class of Levetiracetam?

A

Anticonvulsant

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45
Q

Levetiracetam IV:Oral dosing?

A

Same

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46
Q

What is the brand name of Levofloxacin?

A

Levaquin

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47
Q

What is the class of Levofloxacin?

A

Fluoroquinolone antimicrobial

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48
Q

Levofloxacin coverage…

A

Gram +, Gram -, atypicals (very broad spectrum, used in CA-PNA especially S. pneumonia)

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49
Q

DI with Levofloxacin

A

NSAIDs, warfarin, some antiarrhythmics

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50
Q

Caution with use of Levofloxacin in..

A

Epilepsy, can cause (or exacerbate) prolonged Q-T interval

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51
Q

Levofloxacin dose adjustments

A

Renal impairment (change dosing frequency to every 48 hours vs. every 24 hours)

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52
Q

What is the brand name of Levothyroxine?

A

Synthroid

53
Q

Levothyroxine IV:Oral dosing?

A

IV dose 50% of oral dose

54
Q

What is the brand name of Lidocaine?

A

Xylocaine

55
Q

What is the class of Lidocaine?

A

Local anesthetic and class 1B antiarrhythmic

56
Q

Lidocaine hypersensitivity with…

A

other amide-type anesthetics

57
Q

Forms of Lidocaine

A

Regular and Mixed with Epinephrine

58
Q

Indications of Lidocaine?

A

Used for ventricular arrhythmias and other local anesthesia

59
Q

Max dose for local anesthesia (injectable)

A

4.5 mg/kg/dose; do not repeat within 2 hours

60
Q

What is the brand name of Linezolid?

A

Zyvox

61
Q

What is the class of Linezolid?

A

Oxazolidinone antibiotic (MRSA, VRE, etc)

62
Q

DI with Linezolid?

A

SSRIs, TCAs, and tramadol as it is an inhibitor of MAO

63
Q

Avoid these things while on Linezolid

A

ETOH, Tyramine-containing foods (such as keante wine, fava beans, cheese)

64
Q

What is the brand name of Lorazepam?

A

Ativan

65
Q

What is the class of Lorazepam?

A

Benzodiazepine anti-anxiety agent

66
Q

First-line treatment for status epilepticus, anxiety, and amnesia

A

Lorazepam

67
Q

Vehicle is the problem because it can accumulate

A

Lorazepam IV form is in polyethylene and propylene glycol vehicle –> can lead to hypotension, acidosis, and hyperosmolality

68
Q

Indications of Magnesium Sulfate

A

Torsades de pointe, asthma, anticonvulsant, electrolyte, treatment of eclampsia, pre-eclampsia

69
Q

Dosing of Magnesium Sulfate?

A

Very different between indications (eclampsia/pre-eclampsia dose is very high compared to hypomagnesemia)

70
Q

All IV doses should be given over at least 5 min-1 hour

A

Magnesium Sulfate

71
Q

What is the brand name of Mannitol?

A

Osmitrol

72
Q

What is the class of Mannitol?

A

Osmotic diuretic

73
Q

Indication of Mannitol?

A

Used to pull fluid out of the CNS in an attempt to minimize brain swelling following injury/insult or DKA (intermittent bolus preferred over infusion)

74
Q

Used as a “primer” before nephrotoxic chemotherapy?

A

Mannitol

75
Q

Can crystalize, so you should always administer with a filter

A

Mannitol

76
Q

What is the brand name of Meperidine?

A

Demerol

77
Q

Class of Meperidine?

A

Synthetic opioid (users like it- good rush)

78
Q

Indication for Meperidine?

A

NOT FOR PAIN, has a place in reducing postoperative shivering and reducing rigors from AmphoB

79
Q

Meperidine dose adjustment in…

A

Renal dysfunction (best to avoid)

80
Q

AE of meperidine

A

Active metabolite (normeperidine) can accumulate and lower seizure threshold

81
Q

Just avoid this drug

A

Meperidine

82
Q

Class of MTX?

A

Antimetabolite chemotherapy, DMARD

83
Q

What is the brand name of Methylprednisolone?

A

Solu-Medrol

84
Q

DOC for IV steroids in asthma, COPD, and has use in immunosupression

A

Methylprednisolone

85
Q

Very high doses of Methylprednisolone used in…

A

Acute spinal cord injury and organ rejection (takes grams of this drug)

86
Q

What is the brand name of Metoclopramide?

A

Reglan

87
Q

Pharmacology of Metoclopramide?

A

Stimulates gastic motility (effects on dopaminergic receptors)

88
Q

AEs of Metoclopramide

A

EPS when given with other drugs that cause EPS reactions

89
Q

What is the brand name of Metoprolol?

A

Lopressor

90
Q

Class of Metoprolol?

A

Cardioselective beta-blocker

91
Q

Caution with Metoprolol in…

A

Bradycardia, diabetes (blocks hypoglycemic symptoms), asthma (if you give enough it can affect both types of receptors)

92
Q

Used mainly for early treatment of acute MI, the earlier the better…

A

Metoprolol

93
Q

What is the brand name of Metronidazole?

A

Flagyl

94
Q

Coverage with Metronidazole?

A

Anaerobes and Protozoa

95
Q

DI with Metronidazole?

A

Warfarin, ETOH, Lithium

96
Q

Indications of Metronidazole?

A

Giardia, Intra-abdominal infections, DOC for C.Diff (oral preferred)

97
Q

What is the brand of Micafungin?

A

Mycamine

98
Q

What is the class of Micafungin?

A

Echinocandin antifungal

99
Q

Coverage with Micafungin?

A

Esophageal candidiasis but also for systemic candida infections and aspergillus

100
Q

Brother of “caspo” and “anidula”

A

Micafungin (fewer drug interactions)

101
Q

What is the brand name of Midazolam?

A

Versed

102
Q

What is the class of Midazolam?

A

Short-acting benzodiazepine

103
Q

Indication of Midazolam?

A

Sedation, induction of anesthesia, pre-med for anesthesia or procedure, hypnotic, anticonvulsant

104
Q

Midazolam is ______-soluble?

A

Water-soluble (can be given IM, intranasally, rectally, orally, IV)

105
Q

AE of Midazolam?

A

Retrograde amnesia

106
Q

What is the brand name of Milrinone?

A

Primacor

107
Q

What is the class of Milrinone?

A

Inotropic/vasodilator

108
Q

AEs of Milrinone

A

Hypersensitivity reactions, thrombocytopenia, and hypokalemia

109
Q

Used for short-term (48 hours) treatment of refractory heart failure

A

Milrinone

110
Q

Do not mix Milrinone with…

A

other drugs

111
Q

Use caution with Morphine in..

A

Renal or hepatic dysfunction

112
Q

AE of Morphine

A

Itching (50%) - due to histamine not anaphylaxis (give diphenhydramine)

113
Q

What is the brand name of Nalbuphine?

A

Nubain

114
Q

What is the class of Nalbuphine?

A

Mixed agonist-antagonist opioid

115
Q

What is the brand name of Nesiritide?

A

Natrecor

116
Q

What is the class of Nesiritide?

A

Naturetic peptide for CHF (best for those with high Pulmonary Capillary Wedge Pressure- PCWP and high Systemic Arterial Pressure- SAP)

117
Q

AEs of Nesiritide

A

Hypersensitivity, cardiogenic shock, hypotension (common), KIDNEY EFFECTS/DYSFUNCTION

118
Q

Should be reserved for severe cases of CHF

A

Nesiritide

119
Q

What is the brand name of Naloxone?

A

Narcan

120
Q

What is the class of Naloxone?

A

Pure opioid antagonist

121
Q

Indication of Naloxone?

A

Reversal of opioid overdose (antidote)

122
Q

What is the brand name of Nitroglycerin?

A

Tridil

123
Q

What is the class of Nitroglycerin?

A

Organic nitrate antianginal agent

124
Q

AE of NTG (IV and PO)

A

Headache (you know it works)

125
Q

Indications for NTG

A

Angina, HTN crisis, refractory CHF, pulmonary hypertension

126
Q

What is the brand name of Norepinephrine?

A

Levophed

127
Q

Levophed aka

A

Leave-em-dead

128
Q

What is the class of Norepinephrine?

A

Beta 1 and alpha agonist (alpha > beta)

129
Q

Indication of Norepinephrine?

A

Shock after adequate fluid resuscitation and hypotension

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