Infliximab-Norepinephrine Flashcards
1
Q
What is the brand name of Infliximab?
A
Remicade
2
Q
What is the class of Infliximab?
A
TNF alpha inhibitor
3
Q
Caution with use of Infliximab…
A
In combo with other drugs that affect the immune system
4
Q
Do not give Infliximab to patients with…
A
an active infection (evaluate for TB and get up to date on vaccines)
5
Q
AE of Infliximab
A
Infusion-related reactions (similar to the flu) –> more infusions increases tolerance, but may require pretreatment
6
Q
Very rare AE of Infliximab
A
Hepatosplenic T-cell lymphoma
7
Q
What is the brand name of Iron Dextran Complex?
A
INFeD, Dexferrum
8
Q
What is the class of Iron Dextran Complex?
A
Parenteral iron product
9
Q
AE of Iron Dextran Complex
A
Infusion related reactions (flushing, N/V, diaphoresis, hypotension) - 10% chance
10
Q
Requires a test dose with 1st use…
A
Iron Dextran Complex (INFeD)
11
Q
Z-track method with IM use
A
Iron Dextran Complex (INFeD)
12
Q
What is the brand name of Iron Sucrose?
A
Venofer
13
Q
What is the class of Iron Sucrose?
A
Parenteral iron salt
14
Q
AE of Iron Sucrose
A
Same infusion-related reactions as iron dextran, but not as severe
15
Q
Is a test dose needed with Iron Sucrose?
A
NO
16
Q
Is a test dose needed with Iron Dextran?
A
YES
17
Q
What is the brand name of Isoproterenol?
A
Isuprel
18
Q
What is the class of Isoproterenol?
A
Beta 1,2 agonist
19
Q
Indication of Isoproterenol?
A
Bradyarrhythmias until a pacemaker can be inserted (also used for Torsade De Pointes) –> Short-term drug, not really used for anything else
20
Q
AEs of Isoproterenol
A
Arrhythmias, PVCs, CNS effects, hyperglycemia, hypokalemia, N&V
21
Q
What is the brand name of Ketamine?
A
Ketalar
22
Q
Indication of Ketamine
A
General anesthetic used when cardiodepression must be avoided, also used for sedation and analgesia
23
Q
Also known as Special-K
A
Ketamine
24
Q
Ketamine CI with
A
Increased ICP, HTN, aneurysms, CHF, angina, psychotic disorders (anything that causes BP to go up)
25
Population Ketamine is preferred in
Children, but out-of-body experiences can occur
26
AEs of Ketamine
"Emergent Reactions"- vivid dreams, hallucinations, and delirium can occur up to 24 hours after dose (pre-treatment with benzos), lowers seizure threshold and stimulates salivary secretions
27
Caution with use of Ketamine
Pre-op or patients with cardiac issues
28
What is the brand name of Ketorolac?
Toradol
29
What is the class of Ketorolac?
Super-potent parenteral NSAID
30
30 mg Ketorolac = ___ mg morphine
12
31
Ketorolac CI with...
Active peptic ulcer disease, recent GI bleed, ADVANCED RENAL DISEASE or risk of renal failure, surgery, CVA, s/p CABG
32
Indication of Ketorolac?
Short-term pain management (<5 days only- IV/IM/PO combined)
33
Dose adjustments of Ketorolac?
Reduced if 65 yo, no more than 60 mg/day in moderate renal impairment
34
Do not use Ketorolac in...
advanced renal impairment
35
What is the brand name of Labetolol?
Normodyne, Trandate
36
What is the class of Labetolol?
Non-selective beta blocker and alpha 1 blocker
37
Indication of Labetolol?
BP control
38
What is the brand name of Leucovorin?
Wellcovorin
39
Indication of Leucovorin?
Folic acid derivative used to "rescue" patients from high-dose methotrexate therapy, also used to enhance the effect of 5-FU
40
Critical drug to have on hand
Leucovorin
41
Drugs that Leucovorin must be given with in combo
High-dose MTX, chemotherapy
42
If you aren't clearing MTX fast enough, the hospital will give you more...
Leucovorin
43
What is the brand name of Levetriacetam?
Keppra
44
What is the class of Levetiracetam?
Anticonvulsant
45
Levetiracetam IV:Oral dosing?
Same
46
What is the brand name of Levofloxacin?
Levaquin
47
What is the class of Levofloxacin?
Fluoroquinolone antimicrobial
48
Levofloxacin coverage...
Gram +, Gram -, atypicals (very broad spectrum, used in CA-PNA especially S. pneumonia)
49
DI with Levofloxacin
NSAIDs, warfarin, some antiarrhythmics
50
Caution with use of Levofloxacin in..
Epilepsy, can cause (or exacerbate) prolonged Q-T interval
51
Levofloxacin dose adjustments
Renal impairment (change dosing frequency to every 48 hours vs. every 24 hours)
52
What is the brand name of Levothyroxine?
Synthroid
53
Levothyroxine IV:Oral dosing?
IV dose 50% of oral dose
54
What is the brand name of Lidocaine?
Xylocaine
55
What is the class of Lidocaine?
Local anesthetic and class 1B antiarrhythmic
56
Lidocaine hypersensitivity with...
other amide-type anesthetics
57
Forms of Lidocaine
Regular and Mixed with Epinephrine
58
Indications of Lidocaine?
Used for ventricular arrhythmias and other local anesthesia
59
Max dose for local anesthesia (injectable)
4.5 mg/kg/dose; do not repeat within 2 hours
60
What is the brand name of Linezolid?
Zyvox
61
What is the class of Linezolid?
Oxazolidinone antibiotic (MRSA, VRE, etc)
62
DI with Linezolid?
SSRIs, TCAs, and tramadol as it is an inhibitor of MAO
63
Avoid these things while on Linezolid
ETOH, Tyramine-containing foods (such as keante wine, fava beans, cheese)
64
What is the brand name of Lorazepam?
Ativan
65
What is the class of Lorazepam?
Benzodiazepine anti-anxiety agent
66
First-line treatment for status epilepticus, anxiety, and amnesia
Lorazepam
67
Vehicle is the problem because it can accumulate
Lorazepam IV form is in polyethylene and propylene glycol vehicle --> can lead to hypotension, acidosis, and hyperosmolality
68
Indications of Magnesium Sulfate
Torsades de pointe, asthma, anticonvulsant, electrolyte, treatment of eclampsia, pre-eclampsia
69
Dosing of Magnesium Sulfate?
Very different between indications (eclampsia/pre-eclampsia dose is very high compared to hypomagnesemia)
70
All IV doses should be given over at least 5 min-1 hour
Magnesium Sulfate
71
What is the brand name of Mannitol?
Osmitrol
72
What is the class of Mannitol?
Osmotic diuretic
73
Indication of Mannitol?
Used to pull fluid out of the CNS in an attempt to minimize brain swelling following injury/insult or DKA (intermittent bolus preferred over infusion)
74
Used as a "primer" before nephrotoxic chemotherapy?
Mannitol
75
Can crystalize, so you should always administer with a filter
Mannitol
76
What is the brand name of Meperidine?
Demerol
77
Class of Meperidine?
Synthetic opioid (users like it- good rush)
78
Indication for Meperidine?
NOT FOR PAIN, has a place in reducing postoperative shivering and reducing rigors from AmphoB
79
Meperidine dose adjustment in...
Renal dysfunction (best to avoid)
80
AE of meperidine
Active metabolite (normeperidine) can accumulate and lower seizure threshold
81
Just avoid this drug
Meperidine
82
Class of MTX?
Antimetabolite chemotherapy, DMARD
83
What is the brand name of Methylprednisolone?
Solu-Medrol
84
DOC for IV steroids in asthma, COPD, and has use in immunosupression
Methylprednisolone
85
Very high doses of Methylprednisolone used in...
Acute spinal cord injury and organ rejection (takes grams of this drug)
86
What is the brand name of Metoclopramide?
Reglan
87
Pharmacology of Metoclopramide?
Stimulates gastic motility (effects on dopaminergic receptors)
88
AEs of Metoclopramide
EPS when given with other drugs that cause EPS reactions
89
What is the brand name of Metoprolol?
Lopressor
90
Class of Metoprolol?
Cardioselective beta-blocker
91
Caution with Metoprolol in...
Bradycardia, diabetes (blocks hypoglycemic symptoms), asthma (if you give enough it can affect both types of receptors)
92
Used mainly for early treatment of acute MI, the earlier the better...
Metoprolol
93
What is the brand name of Metronidazole?
Flagyl
94
Coverage with Metronidazole?
Anaerobes and Protozoa
95
DI with Metronidazole?
Warfarin, ETOH, Lithium
96
Indications of Metronidazole?
Giardia, Intra-abdominal infections, DOC for C.Diff (oral preferred)
97
What is the brand of Micafungin?
Mycamine
98
What is the class of Micafungin?
Echinocandin antifungal
99
Coverage with Micafungin?
Esophageal candidiasis but also for systemic candida infections and aspergillus
100
Brother of "caspo" and "anidula"
Micafungin (fewer drug interactions)
101
What is the brand name of Midazolam?
Versed
102
What is the class of Midazolam?
Short-acting benzodiazepine
103
Indication of Midazolam?
Sedation, induction of anesthesia, pre-med for anesthesia or procedure, hypnotic, anticonvulsant
104
Midazolam is ______-soluble?
Water-soluble (can be given IM, intranasally, rectally, orally, IV)
105
AE of Midazolam?
Retrograde amnesia
106
What is the brand name of Milrinone?
Primacor
107
What is the class of Milrinone?
Inotropic/vasodilator
108
AEs of Milrinone
Hypersensitivity reactions, thrombocytopenia, and hypokalemia
109
Used for short-term (48 hours) treatment of refractory heart failure
Milrinone
110
Do not mix Milrinone with...
other drugs
111
Use caution with Morphine in..
Renal or hepatic dysfunction
112
AE of Morphine
Itching (50%) - due to histamine not anaphylaxis (give diphenhydramine)
113
What is the brand name of Nalbuphine?
Nubain
114
What is the class of Nalbuphine?
Mixed agonist-antagonist opioid
115
What is the brand name of Nesiritide?
Natrecor
116
What is the class of Nesiritide?
Naturetic peptide for CHF (best for those with high Pulmonary Capillary Wedge Pressure- PCWP and high Systemic Arterial Pressure- SAP)
117
AEs of Nesiritide
Hypersensitivity, cardiogenic shock, hypotension (common), KIDNEY EFFECTS/DYSFUNCTION
118
Should be reserved for severe cases of CHF
Nesiritide
119
What is the brand name of Naloxone?
Narcan
120
What is the class of Naloxone?
Pure opioid antagonist
121
Indication of Naloxone?
Reversal of opioid overdose (antidote)
122
What is the brand name of Nitroglycerin?
Tridil
123
What is the class of Nitroglycerin?
Organic nitrate antianginal agent
124
AE of NTG (IV and PO)
Headache (you know it works)
125
Indications for NTG
Angina, HTN crisis, refractory CHF, pulmonary hypertension
126
What is the brand name of Norepinephrine?
Levophed
127
Levophed aka
Leave-em-dead
128
What is the class of Norepinephrine?
Beta 1 and alpha agonist (alpha > beta)
129
Indication of Norepinephrine?
Shock after adequate fluid resuscitation and hypotension
