inflammatory bowel disease

Question 1

name 5 IBD conditions?

Answer 1

Ulcerative colitis 
Crohn's disease
Ischaemic colitis 
Radiation colitis 
Appendicitis

Question 2

definition of idiopathic IBD?

Answer 2

chronic inflammatory conditions resulting from inappropriate and persistent activation of mucosal immune system driven by presence of normal intraluminal flora

Question 3

2 components of idiopathic IBD?

Answer 3

crohns

uc

Question 4

aetiology of idiopathic IBD?

Answer 4

strong immune response against normal flora with defects in epithelial barrier function in genetically susceptible individuals

Question 5

% of affected 1st degree relatives in affected idiopathic IBD patients?

Answer 5

15%

Question 6

which gene mutation is seen in Crohns?

Answer 6

NOD2

Question 7

which gene associations in UC?

Answer 7

HLA associations

Question 8

diagnosis of idiopathic IBD?

Answer 8

clinical history, radiology and pathology evidence

Question 9

test for diagnosing idiopathic IBD?

Answer 9

pANCA

Question 10

pANCA’s role in idiopathic IBD?

Answer 10

+ve in 75% UC patients, 11% CD patients

Question 11

issue with pANCA?

Answer 11

is more useful in diagnosing UC patients (75% cases) but only works for 11% of CD patients