Crohn's disease Flashcards
1
Q
F:M ratio?
A
F>M
2
Q
ages affected?
A
any age inc. childhood
3
Q
peak ages affected?
A
20-30yrs and 60-70yrs
4
Q
populations with higher incidence?
A
caucasians, jewish population
5
Q
distribution of CD in the intestines?
A
SI - 40%
LI - 30%
SI and LI - 30%
6
Q
pathology of CD?
A
thickened mesentery skip lesions narrowing of lumen grey appearance of colon "cobblestone" ulceration
7
Q
4 histological features of CD?
A
NON-CASEATING GRANULOMAS
deep ulceration
fibrosis
“chain of pearls” of transmural inflammation
8
Q
5 long term features of CD?
A
SI malabsorption strictures fistulas and abscesses perforation increased risk of malignancy
9
Q
risk of cancer?
A
x5 increased risk
10
Q
CD v.s. UC?
A
CD: colon and ileum affected skip lesions thickened wall moderate fibrosis transmural inflammation
UC: colon only diffuse distributions thin wall mild fibrosis only mucosa is inflammation
11
Q
key difference CD v.s. UC for exam qu?!
A
CD - any part of GI tract
UC - limited to colon
