Inflammatory Bowel Disease Flashcards
Which 3 factors link together in the pathogenesis of IBD?
Genetics
Impaired mucosal immunity
Environmental
Does Crohn’s or UC have a stronger genetic link + gene and chromosome + what it affects?
Crohn’s
NOD2 (IBD-1)
Chromosome 16
Bacterial recognition
Comparison of TH cells for Crohn’s and UC?
Crohn's = TH1 UC = TH1 + TH2
Effect of smoking on Crohn’s and UC?
Crohn's = aggravated US = protects against
Which age range is typical peak incidence of UC?
20-40s but variable
Site of Crohn’s vs UC?
Crohn's = ileum and colon (can be anywhere) UC = rectum and colon
Inflammation depth of Crohn’s vs UC?
Crohn's = transmural UC = superficial
Does Crohn’s or UC have non-caseating granulomas?
Crohn’s
Does Crohn’s or UC have deep fissures?
Crohn’s
Does Crohn’s or UC have extra-GI symptoms + give examples?
UC
Uveitis, arthritis, erythema nodosum
Does Crohn’s or UC cause toxic megacolon?
UC
Does Crohn’s or UC have skip lesions?
Crohn’s
Is perianal disease and fistulas more common in Crohn’s or UC?
Crohn’s
Truelove (It’s fate!) and Witt’s criteria for UC?
> 6 bloody stools Fever Anaemia Tachycardia ESR
Areas of tenderness of Crohn’s vs UC?
Crohn's = RLQ UC = LLQ
Bloody diarrhoea is more associated with Crohn’s or UC?
UC
Treatment algorithm + examples for Crohn’s and UC?
5-ASA/mesalazine (UC only)
Steroids (prednisolone)
Immunosuppresants (aziathropine, methotrexate)
Anti-TNF therapy (IV inflixumab and adalimunab)
Surgery
Aims of surgery in Crohn’s vs UC?
Crohn's = not curatve UC = curative
Steroids are given in short courses for IBD flare ups. True or false?
True
Bloods to do for Crohn’s?
B12
UC has a link to which autoimmune disease?
PSC
Are pseudopolyps associated with Crohn’s or UC?
UC
3 types of UC and where they affect?
Proctitis (rectum)
Left sided colitis (rectum and left colon)
Pancolitis (rectum and whole colon)
Crypt abscesses are associated with Crohn’s or UC?
UC