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Year 1 MBChB Gastrointestinal > Inflammatory Bowel Disease > Flashcards

Inflammatory Bowel Disease Flashcards

1
Q

Which 3 factors link together in the pathogenesis of IBD?

A

Genetics
Impaired mucosal immunity
Environmental

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2
Q

Does Crohn’s or UC have a stronger genetic link + gene and chromosome + what it affects?

A

Crohn’s
NOD2 (IBD-1)
Chromosome 16
Bacterial recognition

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3
Q

Comparison of TH cells for Crohn’s and UC?

A 
Crohn's = TH1
UC = TH1 + TH2
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4
Q

Effect of smoking on Crohn’s and UC?

A 
Crohn's = aggravated
US = protects against
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5
Q

Which age range is typical peak incidence of UC?

A

20-40s but variable

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6
Q

Site of Crohn’s vs UC?

A 
Crohn's =  ileum and colon (can be anywhere)
UC = rectum and colon
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7
Q

Inflammation depth of Crohn’s vs UC?

A 
Crohn's = transmural
UC = superficial
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8
Q

Does Crohn’s or UC have non-caseating granulomas?

A

Crohn’s

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9
Q

Does Crohn’s or UC have deep fissures?

A

Crohn’s

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10
Q

Does Crohn’s or UC have extra-GI symptoms + give examples?

A

UC

Uveitis, arthritis, erythema nodosum

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11
Q

Does Crohn’s or UC cause toxic megacolon?

A

UC

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12
Q

Does Crohn’s or UC have skip lesions?

A

Crohn’s

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13
Q

Is perianal disease and fistulas more common in Crohn’s or UC?

A

Crohn’s

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14
Q

Truelove (It’s fate!) and Witt’s criteria for UC?

A 
> 6 bloody stools
Fever
Anaemia
Tachycardia
ESR
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15
Q

Areas of tenderness of Crohn’s vs UC?

A 
Crohn's = RLQ
UC = LLQ
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16
Q

Bloody diarrhoea is more associated with Crohn’s or UC?

A

UC

17
Q

Treatment algorithm + examples for Crohn’s and UC?

A

5-ASA/mesalazine (UC only)
Steroids (prednisolone)
Immunosuppresants (aziathropine, methotrexate)
Anti-TNF therapy (IV inflixumab and adalimunab)
Surgery

18
Q

Aims of surgery in Crohn’s vs UC?

A 
Crohn's = not curatve
UC = curative
19
Q

Steroids are given in short courses for IBD flare ups. True or false?

A

True

20
Q

Bloods to do for Crohn’s?

A

B12

21
Q

UC has a link to which autoimmune disease?

A

PSC

22
Q

Are pseudopolyps associated with Crohn’s or UC?

A

UC

23
Q

3 types of UC and where they affect?

A

Proctitis (rectum)
Left sided colitis (rectum and left colon)
Pancolitis (rectum and whole colon)

24
Q

Crypt abscesses are associated with Crohn’s or UC?

A

UC

25
Q

Loss of haustra on a barium enema is associated with Crohn’s or UC?

A

UC

26
Q

Does IBD have a risk of colorectal cancer?

A

Yes

Year 1 MBChB Gastrointestinal (15 decks)

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