Inflammation & Spasms Flashcards
Define orthopaedics:
correction of deformities/function impairments of the skeletal system - including associated structures such as muscle, tendon and ligaments.
define inflammation:
an immediate, local response to injury and tissue damage
What are the three main stages of inflammation?
- acute
- early/late subacute
- chronic
define edema:
local or general accumulation of the fluid in interstitial space (swelling caused by fluid leaking into the interstitium due to increased bv permeability)
What chemical mediator helps increase permeability in response to inflammation?
histamine - produced by basophils and mast cells in nearby CT
What is advantageous about increased bv permeability in response to inflammation?
allows for the flow of WBC and some proteins into wound area allowing immune response to address infection
What is the purpose of the healing process?
restore integrity of tissues! (redevelopment of structure via scar tissue creation)
What are 3 components of the repair process?
- re-epithelialization (superficial healing - no scar tissue)
- exudate
- synthesis of new tissue
Define exudate:
mass of cells and fluid that has seeped out of bv’s or an organ (category of edema characterized by protein content)
What could happen if exudate is excessive?
some fibrosis in tissues will occur
Define primary/first intention wound healing:
occurs when there is SOME tissue loss and wound edges are approximated
Define secondary/second intention wound healing:
occurs with excessive tissue loss, edges cannot be easily brought together, healing will be longer through extensive re-epithelialization
What is granulation tissue?
new CT and microscopic bv’s that form on the surface of a wound during healing - main component of fibroblasts.
What are 2 jobs of platelets during the repair process?
- coagulation to reduce blood loss
2. isolate and prevent/reduce bacterial infiltration
What is the role of leukocytes during the repair process?
WBC’s involved in protecting the body against infectious disease and foreign invaders.
What cell functions to stimulate proliferation of fibroblasts and regulate collagen synthesis?
leukocytes
What happens during neoangiogenesis?
New bv’s develop from venules at edge of injury and provide nutrients during cellular activity and then retract during late sub-acute phase
What is the main structural and most abundant protein in the body?
collagen
define endomysium:
areolar CT that covers each individual muscle fiber/cell that helps provide chemical exchange of calcium, sodium and potassium.
define areolar tissues composition:
loose CT that consists of a meshwork of collagen, elastic tissue, and reticular fibers - with many CT cells in between the meshwork of fibers
What are 3 effects of fibroblasts in the repair process?
- synthesizes new collagen fibers
- forms loose CT matrix in the area of tissue loss to replace the clot after the acute phase
- can result in excess scar tissue development
What is the purpose of wound contraction?
To speed the healing process by reducing the need for more scar tissue by reducing wound space (myofibroblasts contain contractile fibers)
When does the wound contraction process peak?
2 weeks after injury but continue into late subacute phase
What happens during the scar remodeling process of healing?
strength of site increases with existing collagen broken down and new collagen made = cross links - adhesions may begin to form and ROM will reduce (chronic phase)
What is the time frame an injury is considered in the acute phase of inflammation?
3-4 days post (4-6days)
What is the time frame an injury is considered in the sub-acute phase of inflammation?
early: 2 days- 3 weeks
Late: 2-3 weeks (possibly longer)
What is the time frame an injury is considered in the chronic phase of inflammation?
Overlaps with sub-acute; 3 weeks- 2 + years