inflammation

Question 1

what could exudate contain

Answer 1

wbc
clotting factors
plateelsts complemtents
antibdies

Question 2

decribe the process of extarvasisation

Answer 2

1. margination - leukocytes assume peripheral postions
2. adhesion molecules - rolling and tumbling
3. diapedesis (moving through the barrier)
4. chemotaxis

Question 3

whats the importance of exudate

Answer 3

1. diluting
2. accelerating lymph flow
3. getting agens out of there (ab,s complement ect)

Question 4

the link between infalmmation and anemia

Answer 4

due to the decrease in iron as ireon decreases in inflammation

Question 5

minutes
hours
days

Answer 5

1. histamine and seratonin
2. calicrinin bradykinin systme
3. prostaglandins and cytokines (profinflmmatpry mediators)

Question 6

which mediators are involved in inflammtion in the arachidonic pathway

Answer 6

both leukotrienes (lipoxygenease) and prostaglandin (cox) pathway

Question 7

The difference between glucocorticoids and insights

Answer 7

glucocorticoids block phospholipase A2 so you get no arachidonic acid produced so both are affected and NSAIDs inhibit just the Cox pathway so no prostaglandins

Question 8

bradikinin pathway

Answer 8

iniated by factor 12, activates the ck system which produces bradykinin ( a dilator ) responsible for pain

Question 9

proliferation

Answer 9

Starts from the periphery

increase the number of leucocytes and repair the tissue

angiogenesis

increase in phagocytosis proliferation of cells of blood and histogenous nature

Question 10

What mechanisms of the body is used to increase the temperature

Answer 10

Shivering
increase metabolism
pili erection
visit construction

Question 11

Temperature reducing responses

Answer 11

sweating vasodilation increasing ventilation

Question 12

ways to bring down a fever

Answer 12

lythic - slowly and gradullay

critic - dangerous because it drops to fast e.g vasodilation- hypotension

Question 13

endogenous and exogenous pyrogens

Answer 13

efogenous
- IL - 1
alpha interfroron

exogenous:
bacterial toxins
heavy metals
steroid hormones

Question 14

treating a fever

Answer 14

treat the underlying casue! like bacterial infection

properly hydrate and feed to replace the fluids lost

give NSAIDS (but caution under 12 years old)

Question 15

main key players in fever

Answer 15

cytokines such as IL - 6 cos that alters the set point and also then activates prostaglandins specifically E2