Inflammation Flashcards
What is Inflammation?
Tissue response to injury or infection, characterised by increased blood flow and entry of leukocytes into tissue
4 cardinal signs of inflammation
Redness, swelling, heat, pain
4 things used in inflammation?
Mast cells,neutrophils, complements, chemokines
What are complements:
A set of about 20 different proteins acting in an enzymatic amplification cascade system to generate a number of active components
3 ways of activating complement are:
Classical, Lectin, Alternative
Activation of complement leads to 3:
Release of peptides active in inflammation
Deposition of C3b which is a powerful opsonin
Membrane damage and lysis
Classical Activation Path:
Ag binds to IgG or IgM
Alternative pathway activation:
Direct interaction with polysaccharide on microbe surfaces, or PRRs used
Lectin Pathway complement Activation:
Bacterial cell walls have sugars, Mannose Binding Lectin recognises the sugar
What do all 3 paths end in making?
C3 convertase that breaks C3 to C3a and C3b
Lectin and classical C3 convertase name:
C4b2a3b
Alt path C3 convertase:
C3bBb3b
What happens after C3 split?
C5 split to C5 a and C5b
What is the membrane attack complex made of?
c5b-c9
How does the membrane attack complex work?
C8 acts like a dagger, C9 forms a pore allowing solutes in and out