Inflammation

Question 1

stages of inflammation

Answer 1

1. blood vessels DILATE
2. Become LEAKY -> edema
3. WBCs enter inflamed tissue

Question 2

Aspirin

Answer 2

• inhibits COX 1 & 2
• antiinflam, antipyretic analgesic
• effects for musculoskeletal pain, but not visceral

Adverse effects

• bleeding
• reye syndrom
  
  • could be fatal –> hepatic necrosis
  • avoid from infants

Question 3

Ibuprofen

Answer 3

• antiinflam, antipyretic, analgesic
• inhibit COX 1 & 2

Adverse effects:

• gastric ulcers, less intense than asprin
• Myocardial iinfarctions

Question 4

Celecoxib

Answer 4

• COX 2 selective (not involved with clotting for blood)
• osteoarthritis antiinflammatory
• poor analgesic

Adverse effect

• reduced flow to kidney = hyptension / renal faiure –> Myocardial infarction/ stroke
• arthritis for chronis use

Do not use for:

• patients with OA or RA
• MI/ stroke/ Hypertension

Question 5

acetaminophen

Answer 5

• inhbits PG synthesis –>antipyretic analgesic
• poor antiinflammatory effect / blood clotting
• NO LONGER CONSIDERED NSAID