Gonadal (testosterone, estrogen) Flashcards
1
Q
Gonadorelin
A
- GnRH stimulation
- for infertility by hypothalamic hypogonadotropic hypogonadism
2
Q
Leuprolide
A
- GnRH suppression
- induce hypogonadism if given continuously
- down regulattion on pituitary and reduced LH/FSH
Use:
- prostatic cancer, benign hyperplasia
- uterine fibroid, endometriosis
- central precocious puberty
- assisted reproductive technology procedures
3
Q
hMG: human menopausal gonadotropins
A
- FSH anaologues
- to stimulate ovarian follicular and sperm development
- NEED TO BE USED w/ LH
4
Q
hCG: human chorionic gonadotropins
A
- LH analogue
- produced in placenta and excreted in human
- used w/ hMG for infertility
5
Q
Androgens
A
responsible for:
- spermatogenesis
- genitalia & secondary sex glands
- deepening of voice, facial hair
- libido and behaviour
- lean body mass
- erythropoiesis
- estradiol - closure of growth plates in long bones
side effects:
- enlarge prostate, acne, mood
- heaptic dysfunction
- sterility
- heaard disease
- women masculinization
6
Q
GnRH agonists
A
- leuprolide
7
Q
Testosterone synthesis
A
- ketconazole
- spironolactone
8
Q
inhibition of 5 a reductase
A
- finasteride
9
Q
androgen receptor anatgonists
A
- treatment for male prostatic cancer, endometriosis
- male baldness
- excessive sex, precocious puberty
- flutamide
- cyproterone
10
Q
L - norgestrel
norethidrone
medroxyprogesterone
A
- synthetic progestins
- most important progestin produced and secreted is progesterone
11
Q
estrogen and progestins
A
actions and effects
- sexual maturation
- breast develop
- secondary sex characteristics
- behaviour
- bone turnover and density
Adverse Effects
- mild
- nausea, headaches, endocrine changes
- Moderare
- weight gain, vaginal uterine trat, infections from reduced mucus
- bleeding
- depression
- Severe
- circulatory, hepatic dysfucntion
12
Q
Mifepristone
A
- antiprogestin
- blocks progesterone’ on endometrium needed for implantation
- given with PGE analogue to increase efficacy
13
Q
oral contraceptives
A
- reduce risk of cancers
- lower incifence of ectopic preg
- amelioration of acne, hirsutism, endoetriosis
14
Q
combined oral contraceptives
A
- prevent preg
- gonadotropin suppression inhibiting ovulation through feedback inhibtiion on HPA; FSH and LH
- thicken cervical mucus
- progestins protect endometrium
15
Q
Clomiphene Citrate
A
- partial estrogen receptor agonist
- neg feedback of estrogen on HPA
- enhance FSH
