dopamine - IGF

Question 1

growth hormone

Answer 1

• stimulates synthesis and release of IF-1 from liver = anabolic effect
• promotes lipolysis, gng, protein synth

Question 2

GH deficiency

Answer 2

• retarded growth or possibly dwarfism
• heritble / acquired
• GHRH defect or pituitary problem (tumor, trauma, infection)
• clinical manifestation:
  
  • cardiovascular, psychosocial problems, dec muscle and bone mass, inc body fat, low enery and reduce stregnth
• diagnosis
  
  • measurement of GH levels
  • may require basal and stim GH levels

Question 3

Somatropin

Answer 3

• recombinant human GH
• monitor IGF-1 levels and height –> stop when growth has ceased

Question 4

Mecasermin

Answer 4

• for children w/ GH receptor defects or antibodies to GH

Question 5

Sermorelin

Answer 5

• synthetic form of GHRH
• NOT USEFUL IF problem is @ level of pituitary

Question 6

GH excess

Answer 6

• gigantism - for young
• excessive linear growth
• acromegaly for adults
  
  • resp/car problem, GI tumors
  • elevated IGF or GH
  • caused by tumor of anterior pituitary

Question 7

ocreotide

Answer 7

• inhibits GH release

Question 8

pegvisomant

Answer 8

• dec IGF-1
• alternative to somatostatin analogs

Question 9

Prolactin

Answer 9

• peptide hormone from anterior pituitary
• receptor siilar to GH
• NO treatment for prolactin deficiencies

too much prolactin = enlarge breast and lactate formation

Question 10

Dopamine

Answer 10

• released from hypothalamus to dec prolactin secretion
• therefore dopamine like drugs can be used to dec prolactin

Question 11

Bromocriptine

cabergolide

Answer 11

• stimulate D2 dopamine receptors in anterior pituitary –> dec prolactin secretion