adrenal corticoids

Question 1

cortisol

Answer 1

• CHO, protein & lipid metab
• anti inflam & immunomodulatory effects
• stress coping
• cardiovascular integrity
• fetal lung surfactant

Question 2

Aldosterone

Answer 2

• fluid and electrolyte balance
  
  • promotes Na+ reabs, H+/K+ excretion
  • activation of Na+ channels where distal collecting tubes + collecting ducts

Question 3

Cushing’s syndrome

Answer 3

• hyperadrenocorticism
• elevated cortisol levels in body
  
  • upper body obesity
  • muscle wasting
• woman > men

Question 4

Mitotane

Answer 4

• adrenocortiosteroid inhibitors
• drug for Cushing’s disease

Question 5

Ketoconazole

Answer 5

• hormone synthesis inhibitors
• most effective

Question 6

Aminogluthimide

Answer 6

• hormone synthesis
• inhibit conversion of cholesterol to P5

Question 7

Trilostane

Answer 7

• Hormone synthesis inhibitors
• inhibit conversion of P5 to progesterone

Question 8

Mifepristone

Answer 8

• glucocoticoid receptor antagonists
• for inoperable patients w/ extopic or adrenal tumors not responding to other therapy.
• last resort

Question 9

Addison’s disease

Answer 9

• Hypoadrenocorticism
• autoimmune disease and adrenal distruction
• steroid withdrawl
• acute
  
  • abrupt withdrawl of long glucocorticoid therapy
  • exacerbation of chronic adrenal insufficiency
  • can treat with IV HYDROCORTISONE
• chronic
  
  • similar to acut but LESS SEVERE
  • long term glucocorticoid replacement
  • can treat with FLUDRICORTISONE

Question 10

non endocrine use of glucocorticoids

Answer 10

• anti-inflam/allergy
• intensive acute / emergency therapy
• immunosuppresive therapy
  
  • overzealous immune system
• neoplasia

Question 11

Spironolactone

Eplerenone

Answer 11

• mineralocorticoid antagonists
• use for primary aldosteronism caused by adrenal adenoma
• hypertension can develop from increased aldosterone.